Literature DB >> 19934292

Targeting histone demethylases in cancer therapy.

Steven Grant1.   

Abstract

A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.

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Year:  2009        PMID： 19934292      PMCID： PMC2803074          DOI： 10.1158/1078-0432.CCR-09-2399

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  10 in total

Review 1.  Translating the histone code.

Authors:  T Jenuwein; C D Allis
Journal:  Science       Date:  2001-08-10       Impact factor: 47.728

Review 2.  The Hedgehog and Wnt signalling pathways in cancer.

Authors:  J Taipale; P A Beachy
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

Review 3.  Dynamic regulation of histone lysine methylation by demethylases.

Authors:  Yang Shi; Johnathan R Whetstine
Journal:  Mol Cell       Date:  2007-01-12       Impact factor: 17.970

Review 4.  Regulation of histone methylation by demethylimination and demethylation.

Authors:  Robert J Klose; Yi Zhang
Journal:  Nat Rev Mol Cell Biol       Date:  2007-03-07       Impact factor: 94.444

Review 5.  Azapyrimidine nucleosides: metabolism and inhibitory mechanisms.

Authors:  A Cihák; J Vesely; J Skoda
Journal:  Adv Enzyme Regul       Date:  1985

6.  Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.

Authors:  Steven D Gore; Stephen Baylin; Elizabeth Sugar; Hetty Carraway; Carole B Miller; Michael Carducci; Michael Grever; Oliver Galm; Tianna Dauses; Judith E Karp; Michelle A Rudek; Ming Zhao; B Douglas Smith; Jasper Manning; Anchalee Jiemjit; George Dover; Abbie Mays; James Zwiebel; Anthony Murgo; Li-Jun Weng; James G Herman
Journal:  Cancer Res       Date:  2006-06-15       Impact factor: 12.701

7.  Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

Authors:  Jose M Polo; Tania Dell'Oso; Stella Maris Ranuncolo; Leandro Cerchietti; David Beck; Gustavo F Da Silva; Gilbert G Prive; Jonathan D Licht; Ari Melnick
Journal:  Nat Med       Date:  2004-11-07       Impact factor: 53.440

Review 8.  The epigenomics of cancer.

Authors:  Peter A Jones; Stephen B Baylin
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

9.  Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Authors:  Yi Huang; Tracy Murray Stewart; Yu Wu; Stephen B Baylin; Laurence J Marton; Brandy Perkins; Richard J Jones; Patrick M Woster; Robert A Casero
Journal:  Clin Cancer Res       Date:  2009-11-24       Impact factor: 12.531

10.  Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.

Authors:  Steven A Belinsky; Donna M Klinge; Christine A Stidley; Jean-Pierre Issa; James G Herman; Thomas H March; Stephen B Baylin
Journal:  Cancer Res       Date:  2003-11-01       Impact factor: 12.701
  10 in total
  12 in total

1.  New functions for the Snail family of transcription factors: Two-faced proteins.

Authors:  Jesús Pérez-Losada; Isidro Sanchez-Garcia
Journal:  Cell Cycle       Date:  2010-07-15       Impact factor: 4.534

Review 2.  The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors:  Anthony R Cyr; Frederick E Domann
Journal:  Antioxid Redox Signal       Date:  2011-02-05       Impact factor: 8.401

3.  Neuroepigenomics: Resources, Obstacles, and Opportunities.

Authors:  John S Satterlee; Andrea Beckel-Mitchener; Roger Little; Dena Procaccini; Joni L Rutter; Amy C Lossie
Journal:  Neuroepigenetics       Date:  2015-01-01

4.  Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer.

Authors:  Jinling Hou; Jack Wu; Alan Dombkowski; Kezhong Zhang; Andreana Holowatyj; Julie L Boerner; Zeng-Quan Yang
Journal:  Am J Transl Res       Date:  2012-07-22       Impact factor: 4.060

Review 5.  Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics.

Authors:  Isaac K Sundar; Nandita Mullapudi; Hongwei Yao; Simon D Spivack; Irfan Rahman
Journal:  Curr Opin Pulm Med       Date:  2011-07       Impact factor: 3.155

6.  Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.

Authors:  Omar Y Mian; Shou Zhen Wang; Sheng Zu Zhu; Merlin N Gnanapragasam; Laura Graham; Harry D Bear; Gordon D Ginder
Journal:  Mol Cancer Res       Date:  2011-06-21       Impact factor: 5.852

7.  JHDM3A module as an effector molecule in guide-directed modification of target chromatin.

Authors:  Young Sun Jeong; Jung Sun Park; Yong Ko; Yong-Kook Kang
Journal:  J Biol Chem       Date:  2010-12-10       Impact factor: 5.157

8.  Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer.

Authors:  Yufeng Huang; Yiqian Liu; Lijiang Yu; Jing Chen; Juan Hou; Lihua Cui; De Ma; Wangkun Lu
Journal:  Tumour Biol       Date:  2014-09-23

9.  Development of substrate-selective probes for affinity pulldown of histone demethylases.

Authors:  Laura J Marholz; Le Chang; William M Old; Xiang Wang
Journal:  ACS Chem Biol       Date:  2014-10-29       Impact factor: 5.100

10.  Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.

Authors:  Jia Liu; Feng-Yu Liu; Zhi-Qian Tong; Zhi-Hua Li; Wen Chen; Wen-Hong Luo; Hui Li; Hong-Jun Luo; Yan Tang; Jun-Min Tang; Jie Cai; Fei-Fei Liao; You Wan
Journal:  PLoS One       Date:  2013-03-14       Impact factor: 3.240
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