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Literature DB >> 25245333

Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer.

Yufeng Huang¹, Yiqian Liu, Lijiang Yu, Jing Chen, Juan Hou, Lihua Cui, De Ma, Wangkun Lu.

Abstract

Histone demethylase KDM2A has been reported to be dysregulated in lung cancer. However, its function in gastric cancer remains poorly understood. Here, it was found that the expression level of KDM2A was increased in gastric cancer tissues. Moreover, forced expression of KDM2A in gastric cancer cells promoted cell growth and migration, while the knockdown expression of KDM2A inhibited the tumorigenicity of gastric cancer cells. Mechanistically, KDM2A regulated the growth and motility of gastric cancer cells through downregulating the expression of programmed cell death 4 (PDCD4), a known tumor suppressor in the progression of gastric cancer. Taken together, our study suggested that upregulation of KDM2A was very important in the progression of gastric cancer, and KDM2A might be a promising therapeutic target.

Entities: Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 25245333 DOI： 10.1007/s13277-014-2630-5

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

41 in total

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Journal: Int J Oncol Date: 2013-05-24 Impact factor: 5.650

6. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G.

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Journal: Cancer Lett Date: 2008-11-13 Impact factor: 8.679

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22 in total

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Journal: Chem Rev Date: 2017-03-24 Impact factor: 60.622

2. Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.

Authors: Arun K Nalla; Theodore F Williams; Casey P Collins; Dustin T Rae; Grant D Trobridge
Journal: Mol Carcinog Date: 2015-10-29 Impact factor: 4.784

Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer.

Review 1. Transcriptional and translational regulation of gene expression in haploid spermatids.

2. Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody.

3. Role of lysine methylation of NF-κB in differential gene regulation.

4. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

5. Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3.

6. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G.

7. Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.

8. Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis.

9. Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Review 10. Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains.

Review 1. Inhibitors of Protein Methyltransferases and Demethylases.

2. Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.

3. ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.

4. Histone demethylase JMJD1C regulates esophageal cancer proliferation Via YAP1 signaling.

Review 5. Histone demethylase KDM2A: Biological functions and clinical values (Review).

6. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer.

7. Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma.

8. Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell.

9. KDM2A Targets PFKFB3 for Ubiquitylation to Inhibit the Proliferation and Angiogenesis of Multiple Myeloma Cells.

Review 10. Lysine Demethylases: Promising Drug Targets in Melanoma and Other Cancers.