Literature DB >> 19933803

Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions.

Melanie L Langford1, Sahar Hasim, Kenneth W Nickerson, Audrey L Atkin.   

Abstract

Farnesol interacts with Candida albicans as both a quorum-sensing molecule and toxic agent, but confusion abounds regarding which conditions promote these distinct responses. Farnesol sensitivity was measured when inoculum cell history and size, temperature, and growth media were altered. Parameters for farnesol tolerance/sensitivity were defined, validating previous studies and identifying new variables, such as energy availability. This study clearly defines what farnesol concentrations are lethal to C. albicans, based on environmental conditions.

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Year:  2009        PMID： 19933803      PMCID： PMC2812148          DOI： 10.1128/AAC.01214-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance.

Authors:  Mary Ann Jabra-Rizk; Mark Shirtliff; Cathy James; Timothy Meiller
Journal:  FEMS Yeast Res       Date:  2006-11       Impact factor: 2.796

2.  In vivo and in vitro anaerobic mating in Candida albicans.

Authors:  Raluca Dumitru; Dhammika H M L P Navarathna; Camile P Semighini; Christian G Elowsky; Razvan V Dumitru; Daniel Dignard; Malcolm Whiteway; Audrey L Atkin; Kenneth W Nickerson
Journal:  Eukaryot Cell       Date:  2007-01-26

3.  Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.

Authors:  Daniel D Mosel; Raluca Dumitru; Jacob M Hornby; Audrey L Atkin; Kenneth W Nickerson
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

Review 4.  Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans.

Authors:  Melanie L Langford; Audrey L Atkin; Kenneth W Nickerson
Journal:  Future Microbiol       Date:  2009-12       Impact factor: 3.165

5.  Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.

Authors:  J M Hornby; E C Jensen; A D Lisec; J J Tasto; B Jahnke; R Shoemaker; P Dussault; K W Nickerson
Journal:  Appl Environ Microbiol       Date:  2001-07       Impact factor: 4.792

6.  Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis.

Authors:  Dhammika H M L P Navarathna; Jacob M Hornby; Natasha Hoerrmann; Anne M Parkhurst; Gerald E Duhamel; Kenneth W Nickerson
Journal:  J Antimicrob Chemother       Date:  2005-10-20       Impact factor: 5.790

7.  Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans.

Authors:  Dhammika H M L P Navarathna; Jacob M Hornby; Navasona Krishnan; Anne Parkhurst; Gerald E Duhamel; Kenneth W Nickerson
Journal:  Infect Immun       Date:  2007-02-05       Impact factor: 3.441

8.  A two-part energy burden imposed by growth of Enterobacter cloacae and Escherichia coli in sodium dodecyl sulfate.

Authors:  A Aspedon; K W Nickerson
Journal:  Can J Microbiol       Date:  1993-06       Impact factor: 2.419

9.  Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs.

Authors:  Raluca Dumitru; Jacob M Hornby; Kenneth W Nickerson
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

10.  Membrane-derived oligosaccharides (MDOs) are essential for sodium dodecyl sulfate resistance in Escherichia coli.

Authors:  Soumitra Rajagopal; Nicole Eis; Meenakshi Bhattacharya; Kenneth W Nickerson
Journal:  FEMS Microbiol Lett       Date:  2003-06-06       Impact factor: 2.742
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  23 in total

1.  Influence of phosphatidylserine and phosphatidylethanolamine on farnesol tolerance in Candida albicans.

Authors:  Sahar Hasim; Elyse N Vaughn; Dallas Donohoe; Donna M Gordon; Susan Pfiffner; Todd B Reynolds
Journal:  Yeast       Date:  2018-02-08       Impact factor: 3.239

2.  Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm.

Authors:  Li-Hua Yu; Xin Wei; Ming Ma; Xiao-Jun Chen; Shuang-Bo Xu
Journal:  Antimicrob Agents Chemother       Date:  2011-11-21       Impact factor: 5.191

Review 3.  Quorum sensing by farnesol revisited.

Authors:  Melanie Polke; Ilse D Jacobsen
Journal:  Curr Genet       Date:  2017-02-28       Impact factor: 3.886

4.  Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway.

Authors:  Aurélie Deveau; Amy E Piispanen; Angelyca A Jackson; Deborah A Hogan
Journal:  Eukaryot Cell       Date:  2010-01-29

5.  Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei.

Authors:  R S N Brilhante; L G A Valente; M F G Rocha; T J P G Bandeira; R A Cordeiro; R A C Lima; J J G Leite; J F Ribeiro; J F Pereira; D S C M Castelo-Branco; A J Monteiro; J J C Sidrim
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

6.  In vitro antibiofilm efficacy of farnesol against Candida species.

Authors:  Mihrinur Yapıcı; Bükay Yenice Gürsu; İlknur Dağ
Journal:  Int Microbiol       Date:  2021-02-18       Impact factor: 2.479

7.  Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response.

Authors:  Amy E Piispanen; Ophelie Bonnefoi; Sarah Carden; Aurelie Deveau; Martine Bassilana; Deborah A Hogan
Journal:  Eukaryot Cell       Date:  2011-09-09

8.  Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii.

Authors:  Raimunda Sâmia Nogueira Brilhante; Rita Amanda Chaves de Lima; Erica Pacheco Caetano; João Jaime Giffoni Leite; Débora de Souza Collares Maia Castelo-Branco; Joyce Fonteles Ribeiro; Tereza de Jesus Pinheiro Gomes Bandeira; Rossana de Aguiar Cordeiro; André Jalles Monteiro; José Júlio Costa Sidrim; Marcos Fábio Gadelha Rocha
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

9.  Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans.

Authors:  Allia K Lindsay; Aurélie Deveau; Amy E Piispanen; Deborah A Hogan
Journal:  Eukaryot Cell       Date:  2012-08-10

10.  Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death.

Authors:  Melanie L Langford; Jessica C Hargarten; Krista D Patefield; Elizabeth Marta; Jill R Blankenship; Saranna Fanning; Kenneth W Nickerson; Audrey L Atkin
Journal:  Eukaryot Cell       Date:  2013-07-19
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