Literature DB >> 19933367

The gene CBO0515 from Clostridium botulinum strain Hall A encodes the rare enzyme N5-(carboxyethyl) ornithine synthase, EC 1.5.1.24.

John Thompson1, Karen K Hill, Theresa J Smith, Andreas Pikis.   

Abstract

Sequencing of the genome of Clostridium botulinum strain Hall A revealed a gene (CBO0515), whose putative amino acid sequence was suggestive of the rare enzyme N(5)-(1-carboxyethyl) ornithine synthase. To test this hypothesis, CBO0515 has been cloned, and the encoded polypeptide was purified and characterized. This unusual gene appears to be confined to proteolytic strains assigned to group 1 of C. botulinum.

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Year:  2009        PMID： 19933367      PMCID： PMC2812957          DOI： 10.1128/JB.01044-09

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  N-(carboxyalkyl)amino acids: occurrence, synthesis, and functions.

Authors:  J Thompson; J A Donkersloot
Journal:  Annu Rev Biochem       Date:  1992       Impact factor: 23.643

2.  Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.

Authors:  K K Hill; T J Smith; C H Helma; L O Ticknor; B T Foley; R T Svensson; J L Brown; E A Johnson; L A Smith; R T Okinaka; P J Jackson; J D Marks
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

3.  Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.

Authors:  P J Baker; Y Sawa; H Shibata; S E Sedelnikova; D W Rice
Journal:  Nat Struct Biol       Date:  1998-07

Review 4.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Authors:  S F Altschul; T L Madden; A A Schäffer; J Zhang; Z Zhang; W Miller; D J Lipman
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

Review 5.  Botulinum toxin as a biological weapon: medical and public health management.

Authors:  S S Arnon; R Schechter; T V Inglesby; D A Henderson; J G Bartlett; M S Ascher; E Eitzen; A D Fine; J Hauer; M Layton; S Lillibridge; M T Osterholm; T O'Toole; G Parker; T M Perl; P K Russell; D L Swerdlow; K Tonat
Journal:  JAMA       Date:  2001-02-28       Impact factor: 56.272

6.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

Authors:  J D Thompson; D G Higgins; T J Gibson
Journal:  Nucleic Acids Res       Date:  1994-11-11       Impact factor: 16.971

7.  Transposon-encoded sucrose metabolism in Lactococcus lactis. Purification of sucrose-6-phosphate hydrolase and genetic linkage to N5-(L-1-carboxyethyl)-L-ornithine synthase in strain K1.

Authors:  J Thompson; N Y Nguyen; D L Sackett; J A Donkersloot
Journal:  J Biol Chem       Date:  1991-08-05       Impact factor: 5.157

8.  Cloning, expression, sequence analysis, and site-directed mutagenesis of the Tn5306-encoded N5-(carboxyethyl)ornithine synthase from Lactococcus lactis K1.

Authors:  J A Donkersloot; J Thompson
Journal:  J Biol Chem       Date:  1995-05-19       Impact factor: 5.157

9.  Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes.

Authors:  Mohammed Sebaihia; Michael W Peck; Nigel P Minton; Nicholas R Thomson; Matthew T G Holden; Wilfrid J Mitchell; Andrew T Carter; Stephen D Bentley; David R Mason; Lisa Crossman; Catherine J Paul; Alasdair Ivens; Marjon H J Wells-Bennik; Ian J Davis; Ana M Cerdeño-Tárraga; Carol Churcher; Michael A Quail; Tracey Chillingworth; Theresa Feltwell; Audrey Fraser; Ian Goodhead; Zahra Hance; Kay Jagels; Natasha Larke; Mark Maddison; Sharon Moule; Karen Mungall; Halina Norbertczak; Ester Rabbinowitsch; Mandy Sanders; Mark Simmonds; Brian White; Sally Whithead; Julian Parkhill
Journal:  Genome Res       Date:  2007-05-22       Impact factor: 9.043

10.  Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum.

Authors:  Andrew T Carter; Catherine J Paul; David R Mason; Susan M Twine; Mark J Alston; Susan M Logan; John W Austin; Michael W Peck
Journal:  BMC Genomics       Date:  2009-03-19       Impact factor: 3.969
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