| Literature DB >> 19932160 |
XiuLing Zheng1, Bing Kan, MaLing Gou, ShaoZhi Fu, Juan Zhang, Ke Men, LiJuan Chen, Feng Luo, YingLan Zhao, Xia Zhao, YuQuan Wei, ZhiYong Qian.
Abstract
Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by (1)H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG-PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery. Copyright 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19932160 DOI： 10.1016/j.ijpharm.2009.11.014
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875