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Literature DB >> 1993157

The effect of smoking on the development of allergic disease and specific immunological responses in a factory workforce exposed to humidifier contaminants.

M J Finnegan¹, S Little, D J Gordon, P K Austwick, R D Tee, A J Nunn, A J Newman-Taylor.
1. Brompton Hospital, London.

Abstract

The effects of smoking on the development of work related asthma and on the production of specific IgE and IgG antibodies to antigen from a contaminated humidifier are described for a sample of 258 workers from a printing factory. Current smoking was associated with low production of IgG antibody but with higher production of IgE antibody. No dose response for either antibody was found when numbers of cigarettes or pack-years smoked were considered. Work related asthma was detected in 12 workers by peak flow recordings. Six were current smokers and one was an ex-smoker. One subject with work related asthma had a high (and one a marginal) concentration of specific IgE to humidifier antigen.

Entities: Disease

Mesh：

Substances：

Year: 1991 PMID： 1993157 PMCID： PMC1035308 DOI： 10.1136/oem.48.1.30

Source DB: PubMed Journal: Br J Ind Med ISSN： 0007-1072

12 in total

The effect of smoking on the development of allergic disease and specific immunological responses in a factory workforce exposed to humidifier contaminants.

1. Effect of cigarette smoking on the specific antibody response in pigeon fanciers.

2. Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy.

3. Factors affecting the development of precipitating antibodies in workers exposed to contaminated humidifiers.

4. Occupational asthma in a factory with a contaminated humidifier.

5. Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate.

6. Immunoglobulin levels in smokers and non-smokers.

7. Airway permeability to horseradish peroxidase in guinea pigs: the repair phase after injury by cigarette smoke.

8. Peak flow rate records in the diagnosis of occupational asthma due to colophony.

9. Peak flow rate records in the diagnosis of occupational asthma due to isocyanates.

10. Increased IgE antibody responses in rats exposed to tobacco smoke.

1. Pigeon fanciers' lung: effects of smoking on serum and salivary antibody responses to pigeon antigens.

2. Discriminant analysis of symptom pattern and serum antibody titres in humidifier related disease.