BACKGROUND: The tumour grading of primary parotid cancers (PPCs) remains controversial. METHODS: A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses. RESULTS: Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age>60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor. CONCLUSION: This study identifies the prognostic significance of intermediate grade tumours. Copyright 2009 Elsevier Ltd. All rights reserved.
BACKGROUND: The tumour grading of primary parotid cancers (PPCs) remains controversial. METHODS: A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses. RESULTS: Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age>60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor. CONCLUSION: This study identifies the prognostic significance of intermediate grade tumours. Copyright 2009 Elsevier Ltd. All rights reserved.
Authors: Tobias Ach; Katharina Zeitler; Stephan Schwarz-Furlan; Katharina Baader; Abbas Agaimy; Christian Rohrmeier; Johannes Zenk; Martin Gosau; Torsten E Reichert; Gero Brockhoff; Tobias Ettl Journal: Virchows Arch Date: 2012-12-15 Impact factor: 4.064
Authors: T Ettl; K Baader; C Stiegler; M Müller; A Agaimy; J Zenk; T Kühnel; M Gosau; K Zeitler; S Schwarz; G Brockhoff Journal: Br J Cancer Date: 2012-01-12 Impact factor: 7.640