Literature DB >> 19926705

Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.

S L Wootton-Gorges1, M H Buonocore, R A Caltagirone, N Kuppermann, N S Glaser.   

Abstract

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

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Year:  2009        PMID： 19926705      PMCID： PMC7964239          DOI： 10.3174/ajnr.A1829

Source DB:  PubMed          Journal:  AJNR Am J Neuroradiol        ISSN： 0195-6108            Impact factor:   3.825


  8 in total

Review 1.  N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.

Authors:  John R Moffett; Brian Ross; Peethambaran Arun; Chikkathur N Madhavarao; Aryan M A Namboodiri
Journal:  Prog Neurobiol       Date:  2007-01-05       Impact factor: 11.685

2.  N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.

Authors:  C Demougeot; P Garnier; C Mossiat; N Bertrand; M Giroud; A Beley; C Marie
Journal:  J Neurochem       Date:  2001-04       Impact factor: 5.372

Review 3.  Cognition and diabetes: a lifespan perspective.

Authors:  Geert Jan Biessels; Ian J Deary; Christopher M Ryan
Journal:  Lancet Neurol       Date:  2008-02       Impact factor: 44.182

4.  Diabetic ketoacidosis and memory dysfunction in children with type 1 diabetes.

Authors:  Simona Ghetti; Joshua K Lee; Clare E Sims; Dana M Demaster; Nicole S Glaser
Journal:  J Pediatr       Date:  2010-01       Impact factor: 4.406

5.  Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis.

Authors:  S L Wootton-Gorges; M H Buonocore; N Kuppermann; J P Marcin; P D Barnes; E K Neely; J DiCarlo; T McCarthy; N S Glaser
Journal:  AJNR Am J Neuroradiol       Date:  2007-05       Impact factor: 3.825

6.  Mechanism of cerebral edema in children with diabetic ketoacidosis.

Authors:  Nicole S Glaser; Sandra L Wootton-Gorges; James P Marcin; Michael H Buonocore; Joseph Dicarlo; E Kirk Neely; Patrick Barnes; Jenny Bottomly; Nathan Kuppermann
Journal:  J Pediatr       Date:  2004-08       Impact factor: 4.406

7.  Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings, and early identification.

Authors:  Andrew B Muir; Ronald G Quisling; Mark C K Yang; Arlan L Rosenbloom
Journal:  Diabetes Care       Date:  2004-07       Impact factor: 19.112

8.  Neuro-cognitive performance in children with type 1 diabetes--a meta-analysis.

Authors:  Justine M Naguib; Elena Kulinskaya; Claire L Lomax; M Elena Garralda
Journal:  J Pediatr Psychol       Date:  2008-07-17
  8 in total
  11 in total

Review 1.  Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain.

Authors:  Ana Maria Arbelaez; Katherine Semenkovich; Tamara Hershey
Journal:  Pediatr Diabetes       Date:  2013-10-14       Impact factor: 4.866

2.  Cerebral Ketones Detected by 3T MR Spectroscopy in Patients with High-Grade Glioma on an Atkins-Based Diet.

Authors:  A Berrington; K C Schreck; B J Barron; L Blair; D D M Lin; A L Hartman; E Kossoff; L Easter; C T Whitlow; Y Jung; F-C Hsu; M C Cervenka; J O Blakeley; P B Barker; R E Strowd
Journal:  AJNR Am J Neuroradiol       Date:  2019-10-24       Impact factor: 3.825

3.  Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife.

Authors:  John P Ryan; Howard J Aizenstein; Trevor J Orchard; Christopher M Ryan; Judith A Saxton; David F Fine; Karen A Nunley; Caterina Rosano
Journal:  Psychosom Med       Date:  2015 Jul-Aug       Impact factor: 4.312

4.  Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism.

Authors:  Nicole Glaser; Catherine Ngo; Steven Anderson; Natalie Yuen; Alexandra Trifu; Martha O'Donnell
Journal:  Diabetes       Date:  2012-04-12       Impact factor: 9.461

5.  Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation.

Authors:  Paolo Fiorina; Paolo Vezzulli; Roberto Bassi; Chiara Gremizzi; Monica Falautano; Francesca D'Addio; Andrea Vergani; Lola Chabtini; Erica Altamura; Alessandra Mello; Rossana Caldara; Marina Scavini; Giuseppe Magnani; Andrea Falini; Antonio Secchi
Journal:  Diabetes Care       Date:  2011-12-21       Impact factor: 19.112

6.  Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children.

Authors:  Fergus J Cameron; Shannon E Scratch; Caroline Nadebaum; Elisabeth A Northam; Ildiko Koves; Juliet Jennings; Kristina Finney; Jeffrey J Neil; R Mark Wellard; Mark Mackay; Terrie E Inder
Journal:  Diabetes Care       Date:  2014-06       Impact factor: 19.112

7.  Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

Authors:  Hatem Hamed Elshorbagy; Naglaa Fathy Barseem; Akram Elshafey Elsadek; Ashraf Hamed Al-shokary; Yehia Hamed Abdel Maksoud; Sameh Elsayed Abdulsamea; Iman M. Talaat; Hany Abdelaziz Suliman; Naglaa M. Kamal; Waleed E. Abdelghani; Sanaa Mohammed Azab; Dalia Mohamed Nour El Din
Journal:  J Clin Res Pediatr Endocrinol       Date:  2019-05-09

8.  Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes.

Authors:  Sage R Myers; Nicole S Glaser; Jennifer L Trainor; Lise E Nigrovic; Aris Garro; Leah Tzimenatos; Kimberly S Quayle; Maria Y Kwok; Arleta Rewers; Michael J Stoner; Jeff E Schunk; Julie K McManemy; Kathleen M Brown; Andrew D DePiero; Cody S Olsen; T Charles Casper; Simona Ghetti; Nathan Kuppermann
Journal:  JAMA Netw Open       Date:  2020-12-01

9.  Effects of Diabetic Ketoacidosis on Visual and Verbal Neurocognitive Function in Young Patients Presenting with New-Onset Type 1 Diabetes.

Authors:  Ashley B Jessup; Mary Beth Grimley; Echo Meyer; Gregory P Passmore; Ayşenil Belger; William H Hoffman; Ali S Çalıkoğlu
Journal:  J Clin Res Pediatr Endocrinol       Date:  2015-09

10.  Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes.

Authors:  Mary E Lacy; Paola Gilsanz; Chloe W Eng; Michal S Beeri; Andrew J Karter; Rachel A Whitmer
Journal:  BMJ Open Diabetes Res Care       Date:  2020-06
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