OBJECTIVE: To conduct meta-analyses of neuropsychological performance in young people with type 1 diabetes. METHODS: Meta-analysis of 24 studies. Studies published between 1980 and 2005 were identified. The inclusion criteria were: young people who were < or =19 years of age with type 1 diabetes, a case-control design and standardized neuropsychological tests of seven cognitive domains. RESULTS: Diabetes was statistically associated with poorer performance on visuospatial ability (d = -0.29), motor speed (d = -0.26) and writing (d = -0.28), on sustained attention (d = -0.21) and reading (d = -0.23). Smaller effects were identified on full IQ (d = -0.14), on performance (d = -0.18) and verbal IQ (d = -0.15). Severe hypoglycemia was linked to deficits in short-term verbal memory (d = -0.14; Confidence Interval: -0.318, 0.024; p =.04). CONCLUSIONS: This meta-analysis indicates that children with type 1 diabetes have mild cognitive impairments and subtly reduced overall intellectual functioning.
OBJECTIVE: To conduct meta-analyses of neuropsychological performance in young people with type 1 diabetes. METHODS: Meta-analysis of 24 studies. Studies published between 1980 and 2005 were identified. The inclusion criteria were: young people who were < or =19 years of age with type 1 diabetes, a case-control design and standardized neuropsychological tests of seven cognitive domains. RESULTS:Diabetes was statistically associated with poorer performance on visuospatial ability (d = -0.29), motor speed (d = -0.26) and writing (d = -0.28), on sustained attention (d = -0.21) and reading (d = -0.23). Smaller effects were identified on full IQ (d = -0.14), on performance (d = -0.18) and verbal IQ (d = -0.15). Severe hypoglycemia was linked to deficits in short-term verbal memory (d = -0.14; Confidence Interval: -0.318, 0.024; p =.04). CONCLUSIONS: This meta-analysis indicates that children with type 1 diabetes have mild cognitive impairments and subtly reduced overall intellectual functioning.
Authors: Anna Maria Patiño-Fernández; Alan M Delamater; E Brooks Applegate; Erika Brady; Margaret Eidson; Robin Nemery; Luis Gonzalez-Mendoza; Samuel Richton Journal: Pediatr Diabetes Date: 2010-04-23 Impact factor: 4.866
Authors: M Allison Cato; Nelly Mauras; Paul Mazaika; Craig Kollman; Peiyao Cheng; Tandy Aye; Jodie Ambrosino; Roy W Beck; Katrina J Ruedy; Allan L Reiss; Michael Tansey; Neil H White; Tamara Hershey Journal: J Int Neuropsychol Soc Date: 2016-01-20 Impact factor: 2.892
Authors: In Kyoon Lyoo; Sujung Yoon; Alan M Jacobson; Jaeuk Hwang; Gail Musen; Jieun E Kim; Donald C Simonson; Sujin Bae; Nicolas Bolo; Dajung J Kim; Katie Weinger; Junghyun H Lee; Christopher M Ryan; Perry F Renshaw Journal: Arch Gen Psychiatry Date: 2012-12