Literature DB >> 19926280

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

Maria M M Santos1, Natália Faria, Jim Iley, Simon J Coles, Michael B Hursthouse, M Luz Martins, Rui Moreira.   

Abstract

We report here a simple entry into naphtho[2,3-d]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19926280     DOI： 10.1016/j.bmcl.2009.10.137

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state.

Authors:  Daniela M Santos; Maria M M Santos; Rui Moreira; Susana Solá; Cecília M P Rodrigues
Journal:  Mol Neurobiol       Date:  2012-10-02       Impact factor: 5.590

2.  Cu/TCH-pr@SBA-15 nano-composite: a new organometallic catalyst for facile three-component synthesis of 4-arylidene-isoxazolidinones.

Authors:  Mehdi Kalhor; Seyed Mehdi Sajjadi; Akbar Dadras
Journal:  RSC Adv       Date:  2020-07-22       Impact factor: 3.361

3.  Protonation Sites, Tandem Mass Spectrometry and Computational Calculations of o-Carbonyl Carbazolequinone Derivatives.

Authors:  Maximiliano Martínez-Cifuentes; Graciela Clavijo-Allancan; Pamela Zuñiga-Hormazabal; Braulio Aranda; Andrés Barriga; Boris Weiss-López; Ramiro Araya-Maturana
Journal:  Int J Mol Sci       Date:  2016-07-05       Impact factor: 5.923

4.  A Novel Small Molecule, LCG-N25, Inhibits Oral Streptococcal Biofilm.

Authors:  Xiaoying Lyu; Chungen Li; Jin Zhang; Liang Wang; Qingsong Jiang; Yusen Shui; Lan Chen; Youfu Luo; Xin Xu
Journal:  Front Microbiol       Date:  2021-03-29       Impact factor: 5.640

5.  A photochemical and theoretical study of the triplet reactivity of furano- and pyrano-1,4-naphthoquionones towards tyrosine and tryptophan derivatives.

Authors:  Rodolfo I Teixeira; Juliana S Goulart; Rodrigo J Corrêa; Simon J Garden; Sabrina B Ferreira; José Carlos Netto-Ferreira; Vitor F Ferreira; Paula Miro; M Luisa Marin; Miguel A Miranda; Nanci C de Lucas
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

6.  Crystal structure and Hirshfeld surface analysis of (Z)-4-(4-hy-droxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one.

Authors:  Wissem Zemamouche; Rima Laroun; Noudjoud Hamdouni; Ouarda Brihi; Ali Boudjada; Abdelmadjid Debache
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-06-08

7.  Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity.

Authors:  Zaibo Yang; Pei Li; Xiuhai Gan
Journal:  Molecules       Date:  2018-07-20       Impact factor: 4.411

8.  Synthesis and microbiological evaluation of new 2- and 2,3-diphenoxysubstituted naphthalene-1,4-diones with 5-oxopyrrolidine moieties.

Authors:  Aušra Voskienė; Birutė Sapijanskaitė; Vytautas Mickevičius; Ilona Jonuškienė; Maryna Stasevych; Olena Komarovska-Porokhnyavets; Rostyslav Musyanovych; Volodymyr Novikov
Journal:  Molecules       Date:  2012-12-05       Impact factor: 4.411
  8 in total

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