SUMMARY:Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients. INTRODUCTION: VCFs of osteoporotic patients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial. METHODS: The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management. RESULTS: The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at 8,800 pound sterling. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits. CONCLUSION: In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting.
RCT Entities:
SUMMARY:Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients. INTRODUCTION: VCFs of osteoporoticpatients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial. METHODS: The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management. RESULTS: The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at 8,800 pound sterling. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits. CONCLUSION: In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting.
Authors: Andrew M Briggs; Tim V Wrigley; Jaap H van Dieën; Bev Phillips; Sing Kai Lo; Alison M Greig; Kim L Bennell Journal: Eur Spine J Date: 2006-07-04 Impact factor: 3.134
Authors: Christian Kasperk; Jochen Hillmeier; Gerd Nöldge; Ingo A Grafe; Katharina Dafonseca; Dorothea Raupp; Hubert Bardenheuer; Martin Libicher; Ute Monika Liegibel; Ulrike Sommer; Ulrike Hilscher; Walter Pyerin; Marcus Vetter; Hans-Peter Meinzer; Peter-Jürgen Meeder; Rod S Taylor; Peter Nawroth Journal: J Bone Miner Res Date: 2004-12-06 Impact factor: 6.741
Authors: Ingo A Grafe; Katharina Da Fonseca; Jochen Hillmeier; Peter-Jürgen Meeder; Martin Libicher; Gerd Nöldge; Hubert Bardenheuer; Walter Pyerin; Linus Basler; Christel Weiss; Rod S Taylor; Peter Nawroth; Christian Kasperk Journal: Osteoporos Int Date: 2005-08-03 Impact factor: 4.507
Authors: F Borgström; D P Beall; S Berven; S Boonen; S Christie; D F Kallmes; J A Kanis; G Olafsson; A J Singer; K Åkesson Journal: Osteoporos Int Date: 2014-11-08 Impact factor: 4.507
Authors: S Boonen; D A Wahl; L Nauroy; M L Brandi; M L Bouxsein; J Goldhahn; E M Lewiecki; G P Lyritis; D Marsh; K Obrant; S Silverman; E Siris; K Akesson Journal: Osteoporos Int Date: 2011-07-26 Impact factor: 4.507