OBJECTIVE: Some studies suggest that depressive subtypes, defined by groups of symptoms, have predictive or diagnostic utility. These studies make the implicit assumption of stability of symptoms across episodes in mood disorders, which has rarely been investigated. METHODS: We examined prospective data from a cohort of 3,750 individuals with bipolar I or II disorder participating in the Systematic Treatment Enhancement Program for Bipolar Disorder study, selecting a subset of individuals who experienced two depressive episodes during up to two years of follow-up. Across-episode association of individual depressive or hypomanic/mixed symptoms was examined using the weighted kappa measure of agreement as well as logistic regression. RESULTS: A total of 583 subjects experienced two prospectively observed depressive episodes, with 149 of those subjects experiencing a third. Greatest evidence of stability was observed for neurovegetative features, suicidality, and guilt/rumination. Loss of interest and fatigue were not consistent across episodes. Structural equation modeling suggested that the dimensional structure of symptoms was not invariant across episodes. CONCLUSION: While the overall dimensional structure of depressive symptoms lacks temporal stability, individual symptoms including suicidality, mood, psychomotor, and neurovegetative symptoms are stable across major depressive episodes in bipolar disorder and should be considered in future investigations of course and pathophysiology in bipolar disorder.
OBJECTIVE: Some studies suggest that depressive subtypes, defined by groups of symptoms, have predictive or diagnostic utility. These studies make the implicit assumption of stability of symptoms across episodes in mood disorders, which has rarely been investigated. METHODS: We examined prospective data from a cohort of 3,750 individuals with bipolar I or II disorder participating in the Systematic Treatment Enhancement Program for Bipolar Disorder study, selecting a subset of individuals who experienced two depressive episodes during up to two years of follow-up. Across-episode association of individual depressive or hypomanic/mixed symptoms was examined using the weighted kappa measure of agreement as well as logistic regression. RESULTS: A total of 583 subjects experienced two prospectively observed depressive episodes, with 149 of those subjects experiencing a third. Greatest evidence of stability was observed for neurovegetative features, suicidality, and guilt/rumination. Loss of interest and fatigue were not consistent across episodes. Structural equation modeling suggested that the dimensional structure of symptoms was not invariant across episodes. CONCLUSION: While the overall dimensional structure of depressive symptoms lacks temporal stability, individual symptoms including suicidality, mood, psychomotor, and neurovegetative symptoms are stable across major depressive episodes in bipolar disorder and should be considered in future investigations of course and pathophysiology in bipolar disorder.
Authors: Gary S Sachs; Michael E Thase; Michael W Otto; Mark Bauer; David Miklowitz; Stephen R Wisniewski; Philip Lavori; Barry Lebowitz; Mathew Rudorfer; Ellen Frank; Andrew A Nierenberg; Maurizio Fava; Charles Bowden; Terence Ketter; Lauren Marangell; Joseph Calabrese; David Kupfer; Jerrold F Rosenbaum Journal: Biol Psychiatry Date: 2003-06-01 Impact factor: 13.382
Authors: Maria A Oquendo; Hanga Galfalvy; Stefani Russo; Steven P Ellis; Michael F Grunebaum; Ainsley Burke; J John Mann Journal: Am J Psychiatry Date: 2004-08 Impact factor: 18.112
Authors: Maria A Oquendo; Andres Barrera; Steven P Ellis; Shuhua Li; Ainsley K Burke; Michael Grunebaum; Jean Endicott; J John Mann Journal: Am J Psychiatry Date: 2004-02 Impact factor: 18.112