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Literature DB >> 19921246

K(ATP) channelopathies in the pancreas.

Abstract

Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic beta-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19921246 DOI： 10.1007/s00424-009-0756-x

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

140 in total

1. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

Authors: F M Gribble; S J Tucker; F M Ashcroft
Journal: EMBO J Date: 1997-03-17 Impact factor: 11.598

Review 2. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes.

Authors: Michael J Riedel; Diana C Steckley; Peter E Light
Journal: Hum Genet Date: 2004-11-23 Impact factor: 4.132

3. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

Authors: O Larsson; J T Deeney; R Bränström; P O Berggren; B E Corkey
Journal: J Biol Chem Date: 1996-05-03 Impact factor: 5.157

4. Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene.

Authors: A S Slingerland; R Nuboer; M Hadders-Algra; A T Hattersley; G J Bruining
Journal: Diabetologia Date: 2006-09-19 Impact factor: 10.122

5. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features.

Authors: Anna L Gloyn; Catherine Diatloff-Zito; Emma L Edghill; Christine Bellanné-Chantelot; Sylvie Nivot; Régis Coutant; Sian Ellard; Andrew T Hattersley; Jean Jacques Robert
Journal: Eur J Hum Genet Date: 2006-05-03 Impact factor: 4.246

6. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Authors: Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; Jerry K H Wales; Penelope Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Journal: N Engl J Med Date: 2004-04-29 Impact factor: 91.245

7. Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.

Authors: Olga T Hardy; Miguel Hernandez-Pampaloni; Janet R Saffer; Joshua S Scheuermann; Linda M Ernst; Richard Freifelder; Hongming Zhuang; Courtney MacMullen; Susan Becker; N Scott Adzick; Chaitanya Divgi; Abass Alavi; Charles A Stanley
Journal: J Clin Endocrinol Metab Date: 2007-09-25 Impact factor: 5.958

8. The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.

Authors: Joseph C Koster; Francesco Cadario; Cinzia Peruzzi; Carlo Colombo; Colin G Nichols; Fabrizio Barbetti
Journal: J Clin Endocrinol Metab Date: 2007-12-11 Impact factor: 5.958

9. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Authors: Richa Saxena; Benjamin F Voight; Valeriya Lyssenko; Noël P Burtt; Paul I W de Bakker; Hong Chen; Jeffrey J Roix; Sekar Kathiresan; Joel N Hirschhorn; Mark J Daly; Thomas E Hughes; Leif Groop; David Altshuler; Peter Almgren; Jose C Florez; Joanne Meyer; Kristin Ardlie; Kristina Bengtsson Boström; Bo Isomaa; Guillaume Lettre; Ulf Lindblad; Helen N Lyon; Olle Melander; Christopher Newton-Cheh; Peter Nilsson; Marju Orho-Melander; Lennart Råstam; Elizabeth K Speliotes; Marja-Riitta Taskinen; Tiinamaija Tuomi; Candace Guiducci; Anna Berglund; Joyce Carlson; Lauren Gianniny; Rachel Hackett; Liselotte Hall; Johan Holmkvist; Esa Laurila; Marketa Sjögren; Maria Sterner; Aarti Surti; Margareta Svensson; Malin Svensson; Ryan Tewhey; Brendan Blumenstiel; Melissa Parkin; Matthew Defelice; Rachel Barry; Wendy Brodeur; Jody Camarata; Nancy Chia; Mary Fava; John Gibbons; Bob Handsaker; Claire Healy; Kieu Nguyen; Casey Gates; Carrie Sougnez; Diane Gage; Marcia Nizzari; Stacey B Gabriel; Gung-Wei Chirn; Qicheng Ma; Hemang Parikh; Delwood Richardson; Darrell Ricke; Shaun Purcell
Journal: Science Date: 2007-04-26 Impact factor: 47.728

10. Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

Authors: S L Shyng; T Ferrigni; J B Shepard; A Nestorowicz; B Glaser; M A Permutt; C G Nichols
Journal: Diabetes Date: 1998-07 Impact factor: 9.461

13 in total

K(ATP) channelopathies in the pancreas.

1. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

Review 2. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes.

3. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

4. Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene.

5. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features.

6. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

7. Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.

8. The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.

9. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

10. Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

Review 1. Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11.

2. A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel.

Review 3. Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.

Review 4. Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.

5. Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations.

6. Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.

Review 7. Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures.

8. Contribution of systemic inflammation to permanence of K_ATP-induced neonatal diabetes in mice.

9. Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.

10. Comparison of K⁺ Channel Families.