Literature DB >> 22134088

Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.

Jerod Scott Denton1, David Aaron Jacobson.   

Abstract

Maintaining blood glucose homeostasis is a complex process that depends on pancreatic islet hormone secretion. Hormone secretion from islets is coupled to calcium entry which results from regenerative islet cell electrical activity. Therefore, the ionic mechanisms that regulate calcium entry into islet cells are crucial for maintaining normal glucose homeostasis. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs), including five located in or near ion-channel or associated subunit genes, which show an association with human diseases characterized by dysglycemia. This review focuses on polymorphisms and mutations in ion-channel genes that are associated with perturbations in human glucose homeostasis and discusses their potential roles in modulating pancreatic islet hormone secretion.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22134088      PMCID： PMC3733341          DOI： 10.1016/j.tem.2011.09.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  87 in total

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Authors:  A S Slingerland; R Nuboer; M Hadders-Algra; A T Hattersley; G J Bruining
Journal:  Diabetologia       Date:  2006-09-19       Impact factor: 10.122

4.  Nutrient control of insulin secretion in isolated normal human islets.

Authors:  Jean-Claude Henquin; Denis Dufrane; Myriam Nenquin
Journal:  Diabetes       Date:  2006-12       Impact factor: 9.461

5.  Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

Authors:  M E Shuck; T M Piser; J H Bock; J L Slightom; K S Lee; M J Bienkowski
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6.  Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion.

Authors:  D W Barnett; D M Pressel; S Misler
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7.  Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Authors:  Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; Jerry K H Wales; Penelope Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Journal:  N Engl J Med       Date:  2004-04-29       Impact factor: 91.245

8.  The sulphonylurea receptor may be an ATP-sensitive potassium channel.

Authors:  N C Sturgess; M L Ashford; D L Cook; C N Hales
Journal:  Lancet       Date:  1985-08-31       Impact factor: 79.321

9.  Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

Authors:  Matthias Braun; Reshma Ramracheya; Martin Bengtsson; Quan Zhang; Jovita Karanauskaite; Chris Partridge; Paul R Johnson; Patrik Rorsman
Journal:  Diabetes       Date:  2008-04-04       Impact factor: 9.461

10.  Successful transfer to sulfonylurea therapy in an infant with developmental delay, epilepsy and neonatal diabetes (DEND) syndrome and a novel ABCC8 gene mutation.

Authors:  N Zwaveling-Soonawala; E E Hagebeuk; A S Slingerland; C Ris-Stalpers; T Vulsma; A S van Trotsenburg
Journal:  Diabetologia       Date:  2010-11-26       Impact factor: 10.122
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Journal:  Insect Biochem Mol Biol       Date:  2014-05-20       Impact factor: 4.714

Review 2.  Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics.

Authors:  Momir Mikov; Maja Đanić; Nebojša Pavlović; Bojan Stanimirov; Svetlana Goločorbin-Kon; Karmen Stankov; Hani Al-Salami
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2018-06       Impact factor: 2.441

3.  Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.

Authors:  Maria S Remedi; Mareen Thomas; Colin G Nichols; Bess A Marshall
Journal:  Pediatr Diabetes       Date:  2017-01-23       Impact factor: 4.866

Review 4.  Ion channel associated diseases: overview of molecular mechanisms.

Authors:  Mark A Zaydman; Jonathan R Silva; Jianmin Cui
Journal:  Chem Rev       Date:  2012-11-14       Impact factor: 60.622

5.  ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI.

Authors:  Ruchira M Jha; Ava M Puccio; David O Okonkwo; Benjamin E Zusman; Seo-Young Park; Jessica Wallisch; Philip E Empey; Lori A Shutter; Robert S B Clark; Patrick M Kochanek; Yvette P Conley
Journal:  Neurocrit Care       Date:  2017-04       Impact factor: 3.210

6.  Direct activation of β-cell KATP channels with a novel xanthine derivative.

Authors:  Rene Raphemot; Daniel R Swale; Prasanna K Dadi; David A Jacobson; Paige Cooper; Andrew P Wojtovich; Sreedatta Banerjee; Colin G Nichols; Jerod S Denton
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7.  Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels.

Authors:  Rene Raphemot; Matthew F Rouhier; Daniel R Swale; Emily Days; C David Weaver; Kimberly M Lovell; Leah C Konkel; Darren W Engers; Sean R Bollinger; Sean F Bollinger; Corey Hopkins; Peter M Piermarini; Jerod S Denton
Journal:  PLoS One       Date:  2014-11-06       Impact factor: 3.240
  7 in total

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