Eswar Krishnan1. 1. Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. e.krishnan@stanford.edu
Abstract
BACKGROUND: Hyperuricemia, a known correlate of oxidative stress, is a marker for adverse prognosis among individuals with heart failure. However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied. METHODS AND RESULTS: We prospectively analyzed the relationship between serum uric acid concentration at baseline and subsequent heart failure among the participants of the Framingham Offspring cohort (n=4912; mean baseline age, 36 years; 52% women). By using Cox regressions, we calculated the risk of heart failure with increasing serum uric acid after adjusting for sex, age, smoking, body mass index, renal dysfunction, diuretics, systolic blood pressure, valvular heart disease, diabetes, alcohol, and use of antihypertensive medications. The incidence rates of heart failure were approximately 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). The adjusted hazard ratio for the highest quartile of serum uric acid compared with the lowest was 2.1 (1.04 to 4.22). The relationship between hyperuricemia and heart failure was found in participants without metabolic syndrome and other subgroups as well. CONCLUSIONS: Hyperuricemia is a novel, independent risk factor for heart failure in a group of young general community dwellers. This has implications for development of preventive strategies for heart failure.
BACKGROUND:Hyperuricemia, a known correlate of oxidative stress, is a marker for adverse prognosis among individuals with heart failure. However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied. METHODS AND RESULTS: We prospectively analyzed the relationship between serum uric acid concentration at baseline and subsequent heart failure among the participants of the Framingham Offspring cohort (n=4912; mean baseline age, 36 years; 52% women). By using Cox regressions, we calculated the risk of heart failure with increasing serum uric acid after adjusting for sex, age, smoking, body mass index, renal dysfunction, diuretics, systolic blood pressure, valvular heart disease, diabetes, alcohol, and use of antihypertensive medications. The incidence rates of heart failure were approximately 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). The adjusted hazard ratio for the highest quartile of serum uric acid compared with the lowest was 2.1 (1.04 to 4.22). The relationship between hyperuricemia and heart failure was found in participants without metabolic syndrome and other subgroups as well. CONCLUSIONS:Hyperuricemia is a novel, independent risk factor for heart failure in a group of young general community dwellers. This has implications for development of preventive strategies for heart failure.
Authors: M Tomita; S Mizuno; H Yamanaka; Y Hosoda; K Sakuma; Y Matuoka; M Odaka; M Yamaguchi; H Yosida; H Morisawa; T Murayama Journal: J Epidemiol Date: 2000-11 Impact factor: 3.211
Authors: Stefan D Anker; Wolfram Doehner; Mathias Rauchhaus; Rakesh Sharma; Darrel Francis; Christoph Knosalla; Constantinos H Davos; Mariantonietta Cicoira; Waqar Shamim; Michel Kemp; Robert Segal; Karl Josef Osterziel; Francisco Leyva; Roland Hetzer; Piotr Ponikowski; Andrew J S Coats Journal: Circulation Date: 2003-04-21 Impact factor: 29.690
Authors: Horacio E Cingolani; Juan A Plastino; Eduardo M Escudero; Brian Mangal; Joanne Brown; Néstor G Pérez Journal: J Card Fail Date: 2006-09 Impact factor: 5.712
Authors: Peter Olexa; Martina Olexová; Jozef Gonsorcík; Ivan Tkác; Jana Kisel'ová; Mária Olejníková Journal: Wien Klin Wochenschr Date: 2002-03-28 Impact factor: 1.704
Authors: Alessandro Maloberti; C Giannattasio; M Bombelli; G Desideri; A F G Cicero; M L Muiesan; E A Rosei; M Salvetti; A Ungar; G Rivasi; R Pontremoli; F Viazzi; R Facchetti; C Ferri; B Bernardino; F Galletti; L D'Elia; P Palatini; E Casiglia; V Tikhonoff; C M Barbagallo; P Verdecchia; S Masi; F Mallamaci; M Cirillo; M Rattazzi; P Pauletto; P Cirillo; L Gesualdo; A Mazza; M Volpe; G Tocci; G Iaccarino; P Nazzaro; L Lippa; G Parati; R Dell'Oro; F Quarti-Trevano; G Grassi; A Virdis; C Borghi Journal: High Blood Press Cardiovasc Prev Date: 2020-03-10