Literature DB >> 1991989

Immunohistochemical localization of parathyroid hormone-related protein (PTHRP) in normal human skin.

E J Atillasoy1, W J Burtis, L M Milstone.   

Abstract

Human keratinocytes secrete large amounts of a parathyroid hormone-related peptide (PTHRP) in vitro. Because recent studies indicate that PTHRP could have a number of autocrine or paracrine functions in the skin, localization of this peptide in vivo is important. A monoclonal and two affinity-purified polyclonal antibodies were employed to locate PTHRP in normal human skin and cultivated human keratinocytes. PTHRP is present throughout the viable portion of the epidermis, in adnexal epithelial cells, and in all cultivated keratinocytes. These findings do not support the provocative suggestion that PTHRP is a marker for squamous differentiation.

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Year:  1991        PMID： 1991989     DOI： 10.1111/1523-1747.ep12464480

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  9 in total

Review 1.  Parathyroid hormone-related protein.

Authors:  R A Nissenson
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

2.  Immunohistochemical localization of parathyroid hormone-related protein (PTHrP) and serum PTHrP in normocalcemic patients with oral squamous cell carcinoma.

Authors:  Makoto Tsuchimochi; Ayako Kameta; Mikiko Sue; Masataka Katagiri
Journal:  Odontology       Date:  2005-09       Impact factor: 2.634

3.  Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.

Authors:  J L Funk; G V Jones; C A Botham; G Morgan; P Wooding; M D Kendall
Journal:  J Anat       Date:  1999-02       Impact factor: 2.610

4.  Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival.

Authors:  Giovanni Almadori; Antonella Coli; Eugenio De Corso; Dario Antonio Mele; Stefano Settimi; Giovanni Di Cintio; Francesca Brigato; Domenico Scannone; Libero Lauriola; Franco Oreste Ranelletti
Journal:  BMC Cancer       Date:  2022-06-27       Impact factor: 4.638

5.  Parathyroid hormone-related protein expression and secretion in a skin organotypic culture system.

Authors:  E A Blomme; J R Werkmeister; H Zhou; V Kartsogiannis; C C Capen; T J Rosol
Journal:  Endocrine       Date:  1998-04       Impact factor: 3.633

6.  Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

Authors:  J J Wysolmerski; A E Broadus; J Zhou; E Fuchs; L M Milstone; W M Philbrick
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

7.  A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.

Authors:  M F Holick; S Ray; T C Chen; X Tian; K S Persons
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

8.  Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation.

Authors:  A van de Stolpe; M Karperien; C W Löwik; H Jüppner; G V Segre; A B Abou-Samra; S W de Laat; L H Defize
Journal:  J Cell Biol       Date:  1993-01       Impact factor: 10.539

9.  Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro.

Authors:  J R Werkmeister; E A Blomme; M T Weckmann; A Gröne; L K McCauley; A B Wade; J O'Rourke; C C Capen; T J Rosol
Journal:  Endocrine       Date:  1998-06       Impact factor: 3.925
  9 in total

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