Literature DB >> 19919847

Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals.

Ajay Semalty1, Mona Semalty, Mohan Singh Maniyari Rawat, Federico Franceschi.   

Abstract

The poor and/or erratic oral bioavailability of polyphenolics can be improved using the PHYTOSOME delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids show affinity for polyphenolics, and form supramolecular adducts having a definite stoichiometry. This article reviews the preparation and characterization of PHYTOSOME complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application. Copyright 2009 Elsevier B.V. All rights reserved.

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Year:  2009        PMID： 19919847     DOI： 10.1016/j.fitote.2009.11.001

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  20 in total

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