| Literature DB >> 19914747 |
Jean-Thomas Pierson1, Aurélien Dumètre, Sébastien Hutter, Florence Delmas, Michèle Laget, Jean-Pierre Finet, Nadine Azas, Sébastien Combes.
Abstract
A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation of human cell line and/or parasites. The 4-(3,4-dimethoxyphenyl)-6,7-dimethoxycoumarin exhibit a potent activity on L. donovani amastigotes with a selectivity index (SI=265) twice than amphotericin B (SI=140). Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2009 PMID： 19914747 DOI： 10.1016/j.ejmech.2009.10.022
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514