| Literature DB >> 19914608 |
Mitchell Thorn1, Rita H Lewis, Alice Mumbey-Wafula, Stefan Kantrowitz, Linda A Spatz.
Abstract
Overexpression of BAFF is believed to play an important role in systemic lupus erythematosus and elevated levels of serum BAFF have been found in lupus patients. Excess BAFF also leads to overproduction of anti-dsDNA antibodies and a lupus-like syndrome in mice. In the present study, we use mice transgenic for the R4A-Cmu (IgM) heavy chain of an anti-dsDNA antibody, to study the effects of BAFF overexpression on anti-dsDNA B-cell regulation. We observe that overexpression of BAFF promotes anti-dsDNA B-cell maturation and secretion of antibody and enriches for transgenic anti-dsDNA B cells in the marginal zone and follicular splenic compartments. In addition, our data suggests that BAFF rescues a subset of anti-dsDNA B cells from a regulatory checkpoint in the transitional stage of development. 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19914608 PMCID： PMC2812582 DOI： 10.1016/j.cellimm.2009.10.004
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868