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Literature DB >> 21752714

BAFF and selection of autoreactive B cells.

Abstract

B cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells, and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF inhibitor, belimumab, is the first new drug in 50 years to be approved for the treatment of SLE. However, the mechanism of action of this drug is not entirely clear. In this review we will focus on the role of the BAFF-APRIL signaling pathway in the selection of autoreactive B cells, and discuss whether altered selection is the mechanism for the therapeutic efficacy of BAFF inhibition in SLE.

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Year: 2011 PMID： 21752714 PMCID： PMC3151317 DOI： 10.1016/j.it.2011.06.004

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

72 in total

1. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

Authors: Marilyn Thien; Tri Giang Phan; Sandra Gardam; Michelle Amesbury; Antony Basten; Fabienne Mackay; Robert Brink
Journal: Immunity Date: 2004-06 Impact factor: 31.745

2. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

Authors: Robin Lesley; Ying Xu; Susan L Kalled; Donna M Hess; Susan R Schwab; Hong-Bing Shu; Jason G Cyster
Journal: Immunity Date: 2004-04 Impact factor: 31.745

3. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death.

Authors: K Kelly; E Manos; G Jensen; L Nadauld; D A Jones
Journal: Cancer Res Date: 2000-02-15 Impact factor: 12.701

4. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein.

Authors: B Pradet-Balade; J P Medema; M López-Fraga; J C Lozano; G M Kolfschoten; A Picard; C Martínez-A; J A Garcia-Sanz; M Hahne
Journal: EMBO J Date: 2002-11-01 Impact factor: 11.598

5. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.

Authors: A E Pugh-Bernard; G J Silverman; A J Cappione; M E Villano; D H Ryan; R A Insel; I Sanz
Journal: J Clin Invest Date: 2001-10 Impact factor: 14.808

6. Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function.

Authors: Kalpit A Vora; Li Chun Wang; Sambasiva P Rao; Zhong-Ying Liu; Gerard R Majeau; Anne H Cutler; Paula S Hochman; Martin L Scott; Susan L Kalled
Journal: J Immunol Date: 2003-07-15 Impact factor: 5.422

7. Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling.

Authors: Wanli Liu; Tobias Meckel; Pavel Tolar; Hae Won Sohn; Susan K Pierce
Journal: Immunity Date: 2010-06-25 Impact factor: 31.745

8. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.

Authors: F Mackay; S A Woodcock; P Lawton; C Ambrose; M Baetscher; P Schneider; J Tschopp; J L Browning
Journal: J Exp Med Date: 1999-12-06 Impact factor: 14.307

9. Enhanced selection of high affinity DNA-reactive B cells following cyclophosphamide treatment in mice.

Authors: Daisuke Kawabata; Jeganathan Venkatesh; Meera Ramanujam; Anne Davidson; Christine M Grimaldi; Betty Diamond
Journal: PLoS One Date: 2010-01-06 Impact factor: 3.240

10. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice.

Authors: Ziaur S M Rahman; Sambasiva P Rao; Susan L Kalled; Tim Manser
Journal: J Exp Med Date: 2003-10-13 Impact factor: 14.307

63 in total

Review 1. Janus-like effects of type I interferon in autoimmune diseases.

Authors: Robert C Axtell; Chander Raman
Journal: Immunol Rev Date: 2012-07 Impact factor: 12.988

Review 2. The rationale for BAFF inhibition in systemic lupus erythematosus.

Authors: Anne Davidson
Journal: Curr Rheumatol Rep Date: 2012-08 Impact factor: 4.592

Review 3. Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.

Authors: Robert C Rickert; Julia Jellusova; Ana V Miletic
Journal: Immunol Rev Date: 2011-11 Impact factor: 12.988

Review 4. Immunopathology of lupus nephritis.

Authors: Hans-Joachim Anders; Agnes B Fogo
Journal: Semin Immunopathol Date: 2014-01-09 Impact factor: 9.623

5. Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents.

Authors: Jin-Ling Shu; Xian-Zheng Zhang; Le Han; Feng Zhang; Yu-Jing Wu; Xiao-Yu Tang; Chen Wang; Yu Tai; Qing-Tong Wang; Jing-Yu Chen; Yan Chang; Hua-Xun Wu; Ling-Ling Zhang; Wei Wei
Journal: Acta Pharmacol Sin Date: 2018-11-16 Impact factor: 6.150

6. DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers.

Authors: Sachin Gupta; Emily S Clark; James M Termini; Justin Boucher; Saravana Kanagavelu; Celia C LeBranche; Sakhi Abraham; David C Montefiori; Wasif N Khan; Geoffrey W Stone
Journal: J Virol Date: 2015-01-28 Impact factor: 5.103

10. Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.

Authors: Wensheng Wang; Javier Rangel-Moreno; Teresa Owen; Jennifer Barnard; Sarah Nevarez; H Travis Ichikawa; Jennifer H Anolik
Journal: J Immunol Date: 2014-02-26 Impact factor: 5.422