Literature DB >> 19913538

Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase.

Alexander B Kotlyar1, Antonio Randazzo, Norman Honbo, Zhu-Qui Jin, Joel S Karliner, Gary Cecchini.   

Abstract

Alkaline incubation of NADH results in the formation of a very potent inhibitor of lactate dehydrogenase. High resolution mass spectroscopy along with NMR characterization clearly showed that the inhibitor is derived from attachment of a glycolic acid moiety to the 4-position of the dihydronicotinamide ring of NADH. The very potent inhibitor is competitive with respect to NADH. The inhibitor added in submicromolar concentrations to cardiomyocytes protects them from damage caused by hypoxia/reoxygenation stress. In isolated mouse hearts, addition of the inhibitor results in a substantial reduction of myocardial infarct size caused by global ischemia/reperfusion injury.

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Year:  2010        PMID： 19913538      PMCID： PMC2794998          DOI： 10.1016/j.febslet.2009.11.022

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  43 in total

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Journal:  Biochemistry       Date:  1978-10-31       Impact factor: 3.162

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Journal:  Am J Cardiol       Date:  1994-03-10       Impact factor: 2.778

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Journal:  Biochemistry       Date:  1984-07-31       Impact factor: 3.162

Review 10.  Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Authors:  Elizabeth Murphy; Charles Steenbergen
Journal:  Physiol Rev       Date:  2008-04       Impact factor: 37.312
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  6 in total

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Journal:  Future Med Chem       Date:  2013-10       Impact factor: 3.808

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Review 3.  Anticancer agents that counteract tumor glycolysis.

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Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

5.  Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.

Authors:  Fahmi Shaher; Shuqiu Wang; Hongbin Qiu; Yu Hu; Yu Zhang; Weiqun Wang; Hisham Al-Ward; Mahfoudh A M Abdulghani; Salem Baldi; Shaobo Zhou
Journal:  Diabetes Metab Syndr Obes       Date:  2020-12-07       Impact factor: 3.168

6.  Transcription elongation factor GreA has functional chaperone activity.

Authors:  Kun Li; Tianyi Jiang; Bo Yu; Limin Wang; Chao Gao; Cuiqing Ma; Ping Xu; Yanhe Ma
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240
  6 in total

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