OBJECTIVES: There is growing biomedical interest in survivin as a diagnostic and prognostic factor in human neoplasms. The present work assessed survivin expression in retinoblastoma. DESIGN AND METHODS: Survivin was quantitatively measured in 82 aqueous humor and serum samples from 41 children with retinoblastoma and nonmalignant ophthalmic diseases. After treatment, 12 serum samples from retinoblastoma patients were included. RESULTS: Survivin levels were higher in aqueous humor and serum of retinoblastoma patients than the controls (P<0.05). In aqueous, it was significantly correlated with the tumor stage and optic nerve affection. The best cutoff values for survivin in aqueous and serum that differentiate between retinoblastoma and nonmalignant ophthalmic diseases were 25.2 pg/mg protein and 12.9 pg/mL, respectively. The sensitivity and specificity were 100% and 90% in serum and 94% and 48% in aqueous, respectively. Serum survivin has decreased significantly after treatment. CONCLUSION: Measurement of survivin protein might have a great diagnostic and prognostic potential in retinoblastoma. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
OBJECTIVES: There is growing biomedical interest in survivin as a diagnostic and prognostic factor in humanneoplasms. The present work assessed survivin expression in retinoblastoma. DESIGN AND METHODS: Survivin was quantitatively measured in 82 aqueous humor and serum samples from 41 children with retinoblastoma and nonmalignant ophthalmic diseases. After treatment, 12 serum samples from retinoblastomapatients were included. RESULTS: Survivin levels were higher in aqueous humor and serum of retinoblastomapatients than the controls (P<0.05). In aqueous, it was significantly correlated with the tumor stage and optic nerve affection. The best cutoff values for survivin in aqueous and serum that differentiate between retinoblastoma and nonmalignant ophthalmic diseases were 25.2 pg/mg protein and 12.9 pg/mL, respectively. The sensitivity and specificity were 100% and 90% in serum and 94% and 48% in aqueous, respectively. Serum survivin has decreased significantly after treatment. CONCLUSION: Measurement of survivin protein might have a great diagnostic and prognostic potential in retinoblastoma. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Authors: Jesse L Berry; Liya Xu; A Linn Murphree; Subramanian Krishnan; Kevin Stachelek; Emily Zolfaghari; Kathleen McGovern; Thomas C Lee; Anders Carlsson; Peter Kuhn; Jonathan W Kim; David Cobrinik; James Hicks Journal: JAMA Ophthalmol Date: 2017-11-01 Impact factor: 7.389
Authors: Robert A Fenstermaker; Sheila A Figel; Jingxin Qiu; Tara A Barone; Sanam S Dharma; Evan K Winograd; Phillip M Galbo; Laura M Wiltsie; Michael J Ciesielski Journal: Clin Cancer Res Date: 2018-03-14 Impact factor: 12.531
Authors: Davide Tamburro; Claudia Fredolini; Virginia Espina; Temple A Douglas; Adarsh Ranganathan; Leopold Ilag; Weidong Zhou; Paul Russo; Benjamin H Espina; Giovanni Muto; Emanuel F Petricoin; Lance A Liotta; Alessandra Luchini Journal: J Am Chem Soc Date: 2011-11-03 Impact factor: 15.419
Authors: Angela Ferrario; Marian Luna; Natalie Rucker; Sam Wong; Ariel Lederman; Jonathan Kim; Charles Gomer Journal: PLoS One Date: 2016-04-06 Impact factor: 3.240