Literature DB >> 19913439

Use of TOF-SIMS to study adsorption and loading behavior of methylene blue and papain in a nano-porous silicon layer.

Ivan M Kempson1, Timothy J Barnes, Clive A Prestidge.   

Abstract

TOF-SIMS was applied to study the cross-sectional distribution of methylene blue and papain in porous silicon layers. Elemental and molecular information were used to study their distributions in the porous region and the chemistry of their adsorption. Methylene blue (MW = 284 Da) penetrated to the base to the pores. Positive ions (SiCH(3)(+)) suggest methylene blue binds to the substrate via its methyl groups. Negative fragments (SiOSH(3)(-) and SiO(2)SCH(-)) also suggested chemisorption via O bridging of the substrate Si and methylene blue S. The larger Papain molecule (23,406 Da) distributed itself in a similar manner to methylene blue demonstrating larger molecules can be effectively incorporated into such pore structures. 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

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Year:  2009        PMID： 19913439     DOI： 10.1016/j.jasms.2009.10.007

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  19 in total

1.  A C60 primary ion beam system for time of flight secondary ion mass spectrometry: its development and secondary ion yield characteristics.

Authors:  Daniel Weibel; Steve Wong; Nicholas Lockyer; Paul Blenkinsopp; Rowland Hill; John C Vickerman
Journal:  Anal Chem       Date:  2003-04-01       Impact factor: 6.986

2.  Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source.

Authors:  David Touboul; Felix Kollmer; Ewald Niehuis; Alain Brunelle; Olivier Laprévote
Journal:  J Am Soc Mass Spectrom       Date:  2005-10       Impact factor: 3.109

Review 3.  Surface chemistry of biodegradable polymers for drug delivery systems.

Authors:  Chang-Sik Ha; Joseph A Gardella
Journal:  Chem Rev       Date:  2005-11       Impact factor: 60.622

Review 4.  Time-of-flight secondary-ion mass spectrometry for the surface characterization of solid-state pharmaceuticals.

Authors:  Clive A Prestidge; Timothy J Barnes; William Skinner
Journal:  J Pharm Pharmacol       Date:  2007-02       Impact factor: 3.765

5.  Hybrid lipid bilayers in nanostructured silicon: a biomimetic mesoporous scaffold for optical detection of cholera toxin.

Authors:  Kristopher A Kilian; Till Böcking; Katharina Gaus; Justin King-Lacroix; Michael Gal; J Justin Gooding
Journal:  Chem Commun (Camb)       Date:  2007-05-21       Impact factor: 6.222

6.  Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion.

Authors:  D M Reffitt; R Jugdaohsingh; R P Thompson; J J Powell
Journal:  J Inorg Biochem       Date:  1999-08-30       Impact factor: 4.155

7.  A novel approach to brachytherapy in hepatocellular carcinoma using a phosphorous32 (32P) brachytherapy delivery device--a first-in-man study.

Authors:  Anthony Soon-Whatt Goh; Alexander Yaw-Fui Chung; Richard Houa-Gong Lo; Te-Neng Lau; Sidney Wing-Kwong Yu; May Chng; Somanesan Satchithanantham; Susan Li-Er Loong; David Chee-Eng Ng; Beng-Choo Lim; Stephen Connor; Pierce Kah-Hoe Chow
Journal:  Int J Radiat Oncol Biol Phys       Date:  2006-12-04       Impact factor: 7.038

8.  An investigation of enhanced secondary ion emission under Au(n)+ (n = 1-7) bombardment.

Authors:  G Nagy; L D Gelb; A V Walker
Journal:  J Am Soc Mass Spectrom       Date:  2005-05       Impact factor: 3.109

9.  Biosensing using porous silicon double-layer interferometers: reflective interferometric Fourier transform spectroscopy.

Authors:  Claudia Pacholski; Marta Sartor; Michael J Sailor; Frédérique Cunin; Gordon M Miskelly
Journal:  J Am Chem Soc       Date:  2005-08-24       Impact factor: 15.419

10.  Covalent biofunctionalization of silicon nitride surfaces.

Authors:  Ahmed Arafat; Marcel Giesbers; Michel Rosso; Ernst J R Sudhölter; Karin Schroën; Richard G White; Li Yang; Matthew R Linford; Han Zuilhof
Journal:  Langmuir       Date:  2007-04-25       Impact factor: 3.882
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  1 in total

Review 1.  Mesoporous Silica Particles as Drug Delivery Systems-The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes.

Authors:  Katarzyna Trzeciak; Agata Chotera-Ouda; Irena I Bak-Sypien; Marek J Potrzebowski
Journal:  Pharmaceutics       Date:  2021-06-24       Impact factor: 6.321
  1 in total

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