Literature DB >> 19913413

Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agents.

Kalpana Bhandari1, Nagarapu Srinivas, Vijay K Marrapu, Aditya Verma, Saumya Srivastava, Suman Gupta.   

Abstract

A series of aryloxy alkyl/aryl alkyl imidazoles were synthesized and evaluated in vitro as antileishmanials against Leishmania donovani. All the 19 compounds exhibited 94-100% inhibition at 10microg/mL against promastigotes and 12 compounds exhibited high inhibition with an IC(50) in the range of 0.47-4.85microg/mL against amastigotes. Promising compounds were tested further in vivo. Among all, compounds 4 and 23 with 4-CF(3) aryloxy moiety exhibited medium in vivo inhibition of 58-60%, thus providing new structural lead for antileishmanials. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19913413     DOI： 10.1016/j.bmcl.2009.10.117

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors:  Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal:  Chem Rev       Date:  2014-11-03       Impact factor: 60.622

2.  In vitro activities of new 2-substituted quinolines against Leishmania donovani.

Authors:  Philippe M Loiseau; Suman Gupta; Aditya Verma; Saumya Srivastava; S K Puri; Faten Sliman; Marie Normand-Bayle; Didier Desmaele
Journal:  Antimicrob Agents Chemother       Date:  2011-01-10       Impact factor: 5.191

3.  DNA Interaction Studies and In Vitro Cytotoxicity of Newly Synthesized Steroidal Imidazolidinones.

Authors:  Ayaz Mahmood Dar; Manzoor Ahmad Gatoo; Ajaz Ahmad; Mir Shabeer Ahmad; Muzaffar Hussain Najar
Journal:  J Fluoresc       Date:  2015-08-06       Impact factor: 2.217

4.  New Series of Imidazoles Showed Promising Growth Inhibitory and Curative Potential Against Trypanosoma Infection.

Authors:  Oluyomi Stephen Adeyemi; Nthatisi Innocentia Molefe-Nyembe; Abiodun Omokehinde Eseola; Winfried Plass; Oluwatosin Kudirat Shittu; Ibrahim Olatunji Yunusa; Olubunmi Atolani; Ikponmwosa Owen Evbuomwan; Oluwakemi J Awakan; Keisuke Suganuma; Kentaro Kato
Journal:  Yale J Biol Med       Date:  2021-06-30
  4 in total

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