| Literature DB >> 19911117 |
Larry Baum1, Iris Hiu Shuen Chan, Stanley Kwok-Kuen Cheung, William B Goggins, Vincent Mok, Linda Lam, Vivian Leung, Elsie Hui, Chelsia Ng, Jean Woo, Helen Fung Kum Chiu, Benny Chung-Ying Zee, William Cheng, Ming-Houng Chan, Samuel Szeto, Victor Lui, Joshua Tsoh, Ashley I Bush, Christopher Wai Kei Lam, Timothy Kwok.
Abstract
Zinc, copper, and iron aggregate Abeta and accumulate in Alzheimer's disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 micromol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p < 0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD.Entities:
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Year: 2009 PMID： 19911117 DOI： 10.1007/s10534-009-9277-5
Source DB: PubMed Journal: Biometals ISSN： 0966-0844 Impact factor: 2.949