BACKGROUND: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. METHODS: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimer's disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimer's Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. RESULTS: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. CONCLUSIONS: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.
BACKGROUND: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. METHODS: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimer's disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimer's Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. RESULTS: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. CONCLUSIONS: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.
Authors: Robert O Wright; Chitra Amarasiriwardena; Alan D Woolf; Rebecca Jim; David C Bellinger Journal: Neurotoxicology Date: 2005-11-28 Impact factor: 4.294
Authors: Zaldy Sy Tan; Sudha Seshadri; Alexa Beiser; Peter W F Wilson; Douglas P Kiel; Michael Tocco; Ralph B D'Agostino; Philip A Wolf Journal: Arch Intern Med Date: 2003-05-12
Authors: Sid E O'Bryant; Valerie Hobson; James R Hall; Stephen C Waring; Wenyan Chan; Paul Massman; Laura Lacritz; C Munro Cullum; Ramon Diaz-Arrastia Journal: J Alzheimers Dis Date: 2009 Impact factor: 4.472
Authors: Neda Firouraghi; Behzad Kiani; Hossein Tabatabaei Jafari; Vincent Learnihan; Jose A Salinas-Perez; Ahmad Raeesi; MaryAnne Furst; Luis Salvador-Carulla; Nasser Bagheri Journal: Int J Health Geogr Date: 2022-08-04 Impact factor: 5.310