| Literature DB >> 19909819 |
Yuko Kawai1, Ichio Aoki, Masahiro Umeda, Toshihiro Higuchi, Jeff Kershaw, Makoto Higuchi, Afonso C Silva, Chuzo Tanaka.
Abstract
Reactive astrogliosis occurs after diverse central nervous system (CNS) insults. While astrogliosis provides protection against inflammation, it is also obstructive in the progress of neuranagenesis after CNS insults. Thus, a method that enables in vivo visualization and tissue characterization for gliosis would be invaluable for studies of CNS insults and corresponding treatments. Manganese has proven to be a useful MRI contrast agent that enters cells via Ca(2+) channels and has been applied to manganese-enhanced MRI (MEMRI) for neuronal functional mapping. This study investigated whether MEMRI can detect astrogliosis after focal ischemia in vivo. Rats were divided into groups according to the number of days after either transient middle cerebral artery occlusion or a sham. Ring- or crescent-shaped enhancement of MEMRI corresponded to the GFAP-positive astroglia observed in the peripheral region of the ischemic core 11 days after middle cerebral artery occlusion. This indicates that MEMRI enhancement predominantly reflects reactive astrogliosis after stroke. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19909819 PMCID： PMC5575780 DOI： 10.1016/j.neuroimage.2009.11.005
Source DB: PubMed Journal: Neuroimage ISSN： 1053-8119 Impact factor: 6.556