Literature DB >> 19909776

Beyond oncology--application of HPMA copolymers in non-cancerous diseases.

Xin-Ming Liu1, Scott C Miller, Dong Wang.   

Abstract

Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed. Copyright 2009 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19909776      PMCID： PMC2821970          DOI： 10.1016/j.addr.2009.10.006

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  131 in total

1.  Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects.

Authors:  Heike Schäcke; Arndt Schottelius; Wolf-Dietrich Döcke; Peter Strehlke; Stefan Jaroch; Norbert Schmees; Hartmut Rehwinkel; Hartwig Hennekes; Khusru Asadullah
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-23       Impact factor: 11.205

Review 2.  Reactive astrocytes: cellular and molecular cues to biological function.

Authors:  J L Ridet; S K Malhotra; A Privat; F H Gage
Journal:  Trends Neurosci       Date:  1997-12       Impact factor: 13.837

3.  Spinal cord reconstruction using NeuroGel implants and functional recovery after chronic injury.

Authors:  S Woerly; V D Doan; F Evans-Martin; C G Paramore; J D Peduzzi
Journal:  J Neurosci Res       Date:  2001-12-15       Impact factor: 4.164

4.  High-molecular weight HPMA copolymer-adriamycin conjugates.

Authors:  M Dvorák; P Kopecková; J Kopecek
Journal:  J Control Release       Date:  1999-08-05       Impact factor: 9.776

5.  The structure of bone apatite surfaces.

Authors:  A S Posner
Journal:  J Biomed Mater Res       Date:  1985-03

Review 6.  Cellular delivery of antisense oligonucleotides.

Authors:  I Lebedeva; L Benimetskaya; C A Stein; M Vilenchik
Journal:  Eur J Pharm Biopharm       Date:  2000-07       Impact factor: 5.571

7.  Local stimulation of new bone formation by prostaglandin E1: quantitative histomorphometry and comparison of delivery by minipumps and controlled-release pellets.

Authors:  S C Miller; S C Marks
Journal:  Bone       Date:  1993 Mar-Apr       Impact factor: 4.398

8.  Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.

Authors:  Xin-Ming Liu; Ling-Dong Quan; Jun Tian; Yazen Alnouti; Kai Fu; Geoffrey M Thiele; Dong Wang
Journal:  Pharm Res       Date:  2008-07-23       Impact factor: 4.200

Review 9.  Diphosphonates: history and mechanisms of action.

Authors:  H Fleisch
Journal:  Metab Bone Dis Relat Res       Date:  1981

10.  Evans blue dye in the assessment of permeability-surface area product in perfused rat lungs.

Authors:  M M Dallal; S W Chang
Journal:  J Appl Physiol (1985)       Date:  1994-08
View more
  8 in total

1.  POLYMERIC BIOMATERIALS AND NANOMEDICINES.

Authors:  Jiyuan Yang; Jindřich Kopeček
Journal:  J Drug Deliv Sci Technol       Date:  2015-12-01       Impact factor: 3.981

2.  Cell delivery of therapeutic nanoparticles.

Authors:  JoEllyn McMillan; Elena Batrakova; Howard E Gendelman
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

Review 3.  Macromolecular therapeutics.

Authors:  Jiyuan Yang; Jindřich Kopeček
Journal:  J Control Release       Date:  2014-04-18       Impact factor: 9.776

Review 4.  Polymer-drug conjugates: origins, progress to date and future directions.

Authors:  Jindřich Kopeček
Journal:  Adv Drug Deliv Rev       Date:  2012-11-02       Impact factor: 15.470

5.  Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.

Authors:  Ling-dong Quan; P Edward Purdue; Xin-ming Liu; Michael D Boska; Subodh M Lele; Geoffrey M Thiele; Ted R Mikuls; Huanyu Dou; Steven R Goldring; Dong Wang
Journal:  Arthritis Res Ther       Date:  2010-09-13       Impact factor: 5.156

6.  Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes.

Authors:  Lingdong Quan; Yijia Zhang; Bart J Crielaard; Anand Dusad; Subodh M Lele; Cristianne J F Rijcken; Josbert M Metselaar; Hana Kostková; Tomáš Etrych; Karel Ulbrich; Fabian Kiessling; Ted R Mikuls; Wim E Hennink; Gert Storm; Twan Lammers; Dong Wang
Journal:  ACS Nano       Date:  2013-12-27       Impact factor: 15.881

Review 7.  Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications.

Authors:  Larissa Y Rizzo; Benjamin Theek; Gert Storm; Fabian Kiessling; Twan Lammers
Journal:  Curr Opin Biotechnol       Date:  2013-04-09       Impact factor: 9.740

8.  In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.

Authors:  Geoffrey M Lynn; Richard Laga; Patricia A Darrah; Andrew S Ishizuka; Alexandra J Balaci; Andrés E Dulcey; Michal Pechar; Robert Pola; Michael Y Gerner; Ayako Yamamoto; Connor R Buechler; Kylie M Quinn; Margery G Smelkinson; Ondrej Vanek; Ryan Cawood; Thomas Hills; Olga Vasalatiy; Kathrin Kastenmüller; Joseph R Francica; Lalisa Stutts; Janine K Tom; Keun Ah Ryu; Aaron P Esser-Kahn; Tomas Etrych; Kerry D Fisher; Leonard W Seymour; Robert A Seder
Journal:  Nat Biotechnol       Date:  2015-10-26       Impact factor: 54.908
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.