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Literature DB >> 19907144

The role of hepcidin in iron metabolism.

Abstract

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory. Copyright 2009 S. Karger AG, Basel.

Entities: Chemical Disease Gene

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Year: 2009 PMID： 19907144 PMCID： PMC2855274 DOI： 10.1159/000243791

Source DB: PubMed Journal: Acta Haematol ISSN： 0001-5792 Impact factor: 2.195

25 in total

1. Hepcidin and iron-loading anemias.

Authors: Elizabeta Nemeth; Tomas Ganz
Journal: Haematologica Date: 2006-06 Impact factor: 9.941

2. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.

Authors: Tapasree Goswami; Nancy C Andrews
Journal: J Biol Chem Date: 2006-08-07 Impact factor: 5.157

3. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.

Authors: Elizabeta Nemeth; Gloria C Preza; Chun-Ling Jung; Jerry Kaplan; Alan J Waring; Tomas Ganz
Journal: Blood Date: 2005-09-01 Impact factor: 22.113

4. Suppression of hepcidin during anemia requires erythropoietic activity.

Authors: Mihwa Pak; Miguel A Lopez; Victroia Gabayan; Tomas Ganz; Seth Rivera
Journal: Blood Date: 2006-08-01 Impact factor: 22.113

5. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

Authors: Rui-Hong Wang; Cuiling Li; Xiaoling Xu; Yin Zheng; Cuiying Xiao; Patricia Zerfas; Sharon Cooperman; Michael Eckhaus; Tracey Rouault; Lopa Mishra; Chu-Xia Deng
Journal: Cell Metab Date: 2005-12 Impact factor: 27.287

6. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.

Authors: Seth Rivera; Elizabeta Nemeth; Victoria Gabayan; Miguel A Lopez; Dina Farshidi; Tomas Ganz
Journal: Blood Date: 2005-06-02 Impact factor: 22.113

7. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.

Authors: Gaël Nicolas; Lydie Viatte; Dan-Qing Lou; Myriam Bennoun; Carole Beaumont; Axel Kahn; Nancy C Andrews; Sophie Vaulont
Journal: Nat Genet Date: 2003-05 Impact factor: 38.330

8. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

Authors: Adriana Donovan; Christine A Lima; Jack L Pinkus; Geraldine S Pinkus; Leonard I Zon; Sylvie Robine; Nancy C Andrews
Journal: Cell Metab Date: 2005-03 Impact factor: 27.287

9. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.

Authors: Vera Niederkofler; Rishard Salie; Silvia Arber
Journal: J Clin Invest Date: 2005-08 Impact factor: 14.808

10. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

Authors: Elizabeta Nemeth; Seth Rivera; Victoria Gabayan; Charlotte Keller; Sarah Taudorf; Bente K Pedersen; Tomas Ganz
Journal: J Clin Invest Date: 2004-05 Impact factor: 14.808

142 in total

1. Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levels.

Authors: Oya Yonal; Filiz Akyuz; Kadir Demir; Sevgi Ciftci; Fahriye Keskin; Binnur Pinarbasi; Ahmet Uyanikoglu; Halim Issever; Sadakat Ozdil; Gungor Boztas; Fatih Besisik; Sabahattin Kaymakoglu; Yilmaz Cakaloglu; Zeynel Mungan; Atilla Okten
Journal: Dig Dis Sci Date: 2010-03-18 Impact factor: 3.199

Review 2. Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.

Authors: Sara Gardenghi; Robert W Grady; Stefano Rivella
Journal: Hematol Oncol Clin North Am Date: 2010-10-15 Impact factor: 3.722

10. Sex-related differences in gene expression following Coxiella burnetii infection in mice: potential role of circadian rhythm.

Authors: Julien Textoris; Leang Heng Ban; Christian Capo; Didier Raoult; Marc Leone; Jean-Louis Mege
Journal: PLoS One Date: 2010-08-13 Impact factor: 3.240

The role of hepcidin in iron metabolism.

1. Hepcidin and iron-loading anemias.

2. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.

3. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.

4. Suppression of hepcidin during anemia requires erythropoietic activity.

5. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

6. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.

7. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.

8. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

9. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.

10. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

1. Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levels.

Review 2. Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.

3. Urinary hepcidin-25 and risk of acute kidney injury following cardiopulmonary bypass.

4. Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients.

Review 5. The long history of iron in the Universe and in health and disease.

6. Early effects of erythropoietin on serum hepcidin and serum iron bioavailability in healthy volunteers.

7. Impact of graphene-based nanomaterials (GBNMs) on the structural and functional conformations of hepcidin peptide.

Review 8. Erythropoiesis-stimulating agents for anemia in rheumatoid arthritis.

9. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.

10. Sex-related differences in gene expression following Coxiella burnetii infection in mice: potential role of circadian rhythm.