Literature DB >> 19906923

Androgen stimulates transcription and replication of xenotropic murine leukemia virus-related virus.

Beihua Dong1, Robert H Silverman.   

Abstract

Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients. Because androgens stimulate prostate tumors and some retroviruses, we investigated the effects of dihydrotestosterone (DHT) on XMRV transcription and replication. Transcription from the XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells containing a functional androgen receptor. Mutations in the glucocorticoid response element (GRE) of XMRV impaired basal transcription and androgen responsiveness. Furthermore, DHT stimulated XMRV replication 3-fold, whereas androgen inhibitors (casodex and flutamide) suppressed viral growth up to 3-fold. Findings suggest that integration of the XMRV long terminal repeat (LTR) into host DNA could impart androgen stimulation on cellular genes.

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Year:  2009        PMID： 19906923      PMCID： PMC2812331          DOI： 10.1128/JVI.01763-09

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Mechanism of histone H1-stimulated glucocorticoid receptor DNA binding in vivo.

Authors:  Sergey Belikov; Carolina Astrand; Orjan Wrange
Journal:  Mol Cell Biol       Date:  2007-01-08       Impact factor: 4.272

2.  Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter.

Authors:  K B Cleutjens; C C van Eekelen; H A van der Korput; A O Brinkmann; J Trapman
Journal:  J Biol Chem       Date:  1996-03-15       Impact factor: 5.157

3.  PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor.

Authors:  Ivan V Litvinov; Lizamma Antony; Susan L Dalrymple; Robyn Becker; Linzhao Cheng; John T Isaacs
Journal:  Prostate       Date:  2006-09-01       Impact factor: 4.104

4.  Assays for retroviral reverse transcriptase.

Authors:  A Telesnitsky; S Blain; S P Goff
Journal:  Methods Enzymol       Date:  1995       Impact factor: 1.600

5.  An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.

Authors:  Beihua Dong; Sanggu Kim; Seunghee Hong; Jaydip Das Gupta; Krishnamurthy Malathi; Eric A Klein; Don Ganem; Joseph L Derisi; Samson A Chow; Robert H Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-18       Impact factor: 11.205

6.  Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.

Authors:  Emily C Knouf; Michael J Metzger; Patrick S Mitchell; Jason D Arroyo; John R Chevillet; Muneesh Tewari; A Dusty Miller
Journal:  J Virol       Date:  2009-04-29       Impact factor: 5.103

7.  Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.

Authors:  Sanggu Kim; Namshin Kim; Beihua Dong; David Boren; Serena A Lee; Jaydip Das Gupta; Christina Gaughan; Eric A Klein; Christopher Lee; Robert H Silverman; Samson A Chow
Journal:  J Virol       Date:  2008-08-06       Impact factor: 5.103

8.  Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

Authors:  Vincent C Lombardi; Francis W Ruscetti; Jaydip Das Gupta; Max A Pfost; Kathryn S Hagen; Daniel L Peterson; Sandra K Ruscetti; Rachel K Bagni; Cari Petrow-Sadowski; Bert Gold; Michael Dean; Robert H Silverman; Judy A Mikovits
Journal:  Science       Date:  2009-10-08       Impact factor: 47.728

9.  XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.

Authors:  Robert Schlaberg; Daniel J Choe; Kristy R Brown; Harshwardhan M Thaker; Ila R Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-08       Impact factor: 11.205

10.  A glucocorticoid response element in the LTR U3 region of Friend murine leukaemia virus variant FIS-2 enhances virus production in vitro and is a major determinant for sex differences in susceptibility to FIS-2 infection in vivo.

Authors:  Torunn Bruland; Liss Anne S Lavik; Hong Yan Dai; Are Dalen
Journal:  J Gen Virol       Date:  2003-04       Impact factor: 3.891
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  20 in total

1.  XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).

Authors:  Jui Pandhare-Dash; Chinmay K Mantri; Yuanying Gong; Zhenbang Chen; Chandravanu Dash
Journal:  Prostate       Date:  2011-09-19       Impact factor: 4.104

2.  NF-kappaB activation stimulates transcription and replication of retrovirus XMRV in human B-lineage and prostate carcinoma cells.

Authors:  Shuhei Sakakibara; Kaori Sakakibara; Giovanna Tosato
Journal:  J Virol       Date:  2011-01-26       Impact factor: 5.103

3.  In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.

Authors:  Ao Zhang; Hal Bogerd; Francois Villinger; Jaydip Das Gupta; Beihua Dong; Eric A Klein; John Hackett; Gerald Schochetman; Bryan R Cullen; Robert H Silverman
Journal:  Virology       Date:  2011-10-06       Impact factor: 3.616

4.  Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Authors:  James N Baraniuk
Journal:  Curr Allergy Asthma Rep       Date:  2010-05       Impact factor: 4.806

5.  Circumcision and the risk of prostate cancer.

Authors:  Jonathan L Wright; Daniel W Lin; Janet L Stanford
Journal:  Cancer       Date:  2012-03-12       Impact factor: 6.860

6.  Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV.

Authors:  Nattawat Onlamoon; Jaydip Das Gupta; Prachi Sharma; Kenneth Rogers; Suganthi Suppiah; Jeanne Rhea; Ross J Molinaro; Christina Gaughan; Beihua Dong; Eric A Klein; Xiaoxing Qiu; Sushil Devare; Gerald Schochetman; John Hackett; Robert H Silverman; François Villinger
Journal:  J Virol       Date:  2011-02-16       Impact factor: 5.103

Review 7.  The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Authors:  Robert H Silverman; Carvell Nguyen; Christopher J Weight; Eric A Klein
Journal:  Nat Rev Urol       Date:  2010-06-01       Impact factor: 14.432

8.  Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.

Authors:  Alice Rusmevichientong; Samson A Chow
Journal:  Immunol Res       Date:  2010-12       Impact factor: 2.829

9.  Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cells.

Authors:  Jason J Rodriguez; Stephen P Goff
Journal:  J Virol       Date:  2009-12-16       Impact factor: 5.103

10.  Prevention of contamination by xenotropic murine leukemia virus-related virus: susceptibility to alcohol-based disinfectants and environmental stability.

Authors:  David Palesch; Mohammad Khalid; Christina M Stürzel; Jan Münch
Journal:  Appl Environ Microbiol       Date:  2014-02-14       Impact factor: 4.792
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