Literature DB >> 21982221

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.

Ao Zhang1, Hal Bogerd, Francois Villinger, Jaydip Das Gupta, Beihua Dong, Eric A Klein, John Hackett, Gerald Schochetman, Bryan R Cullen, Robert H Silverman.   

Abstract

The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DNA from peripheral blood mononuclear cells of XMRV-infected rhesus macaques. Hypermutation characteristic of A3DE, A3F and A3G activities was observed in the XMRV proviral sequences in vivo. Furthermore, expression of rhesus A3DE, A3F, or A3G in human cells inhibited XMRV infection and caused hypermutation of XMRV DNA. These studies show that some rhesus A3 isoforms are highly effective against XMRV in the blood of a non-human primate model of infection and in cultured human cells. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21982221      PMCID： PMC3208790          DOI： 10.1016/j.virol.2011.08.030

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  28 in total

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2.  Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins.

Authors:  Cesar A Virgen; Theodora Hatziioannou
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103

Review 3.  HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

Authors:  Michael H Malim; Michael Emerman
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4.  XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.

Authors:  Rebecca S Arnold; Natalia V Makarova; Adeboye O Osunkoya; Suganthi Suppiah; Takara A Scott; Nicole A Johnson; Sushma M Bhosle; Dennis Liotta; Eric Hunter; Fray F Marshall; Hinh Ly; Ross J Molinaro; Jerry L Blackwell; John A Petros
Journal:  Urology       Date:  2010-04       Impact factor: 2.649

5.  Recombinant origin of the retrovirus XMRV.

Authors:  Tobias Paprotka; Krista A Delviks-Frankenberry; Oya Cingöz; Anthony Martinez; Hsing-Jien Kung; Clifford G Tepper; Wei-Shau Hu; Matthew J Fivash; John M Coffin; Vinay K Pathak
Journal:  Science       Date:  2011-05-31       Impact factor: 47.728

6.  Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells.

Authors:  M Janini; M Rogers; D R Birx; F E McCutchan
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

7.  Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction.

Authors:  Eric W Refsland; Mark D Stenglein; Keisuke Shindo; John S Albin; William L Brown; Reuben S Harris
Journal:  Nucleic Acids Res       Date:  2010-03-22       Impact factor: 16.971

8.  Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates.

Authors:  Véronique Zennou; Paul D Bieniasz
Journal:  Virology       Date:  2006-02-07       Impact factor: 3.616

9.  Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.

Authors:  Fransje A Koning; Edmund N C Newman; Eun-Young Kim; Kevin J Kunstman; Steven M Wolinsky; Michael H Malim
Journal:  J Virol       Date:  2009-07-08       Impact factor: 5.103

10.  XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.

Authors:  Robert Schlaberg; Daniel J Choe; Kristy R Brown; Harshwardhan M Thaker; Ila R Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-08       Impact factor: 11.205
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  6 in total

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Authors:  Khanh Soliven; Xiaoxing Wang; Christopher T Small; Mostafa M Feeroz; Eun-Gyung Lee; Karen L Craig; Kamrul Hasan; Gregory A Engel; Lisa Jones-Engel; Frederick A Matsen; Maxine L Linial
Journal:  J Virol       Date:  2013-10-09       Impact factor: 5.103

Review 2.  Recombinant origin, contamination, and de-discovery of XMRV.

Authors:  Krista Delviks-Frankenberry; Oya Cingöz; John M Coffin; Vinay K Pathak
Journal:  Curr Opin Virol       Date:  2012-07-19       Impact factor: 7.090

3.  An Alu Element Insertion in Intron 1 Results in Aberrant Alternative Splicing of APOBEC3G Pre-mRNA in Northern Pig-Tailed Macaques (Macaca leonina) That May Reduce APOBEC3G-Mediated Hypermutation Pressure on HIV-1.

Authors:  Xiao-Liang Zhang; Meng-Ting Luo; Jia-Hao Song; Wei Pang; Yong-Tang Zheng
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103

4.  No evidence of xenotropic murine leukemia virus-related virus transmission by blood transfusion from infected rhesus macaques.

Authors:  Dhanya K Williams; Teresa A Galvin; Yamei Gao; Christina O'Neill; Dustin Glasner; Arifa S Khan
Journal:  J Virol       Date:  2012-12-12       Impact factor: 5.103

5.  Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques.

Authors:  Gregory Q Del Prete; Mary F Kearney; Jon Spindler; Ann Wiegand; Elena Chertova; James D Roser; Jacob D Estes; Xing Pei Hao; Charles M Trubey; Abigail Lara; Kyeongeun Lee; Chawaree Chaipan; Julian W Bess; Kunio Nagashima; Brandon F Keele; Rhonda Macallister; Jeremy Smedley; Vinay K Pathak; Vineet N Kewalramani; John M Coffin; Jeffrey D Lifson
Journal:  J Virol       Date:  2012-01-11       Impact factor: 5.103

6.  A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.

Authors:  Frederick A Matsen; Christopher T Small; Khanh Soliven; Gregory A Engel; Mostafa M Feeroz; Xiaoxing Wang; Karen L Craig; M Kamrul Hasan; Michael Emerman; Maxine L Linial; Lisa Jones-Engel
Journal:  PLoS Comput Biol       Date:  2014-02-27       Impact factor: 4.475
  6 in total

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