OBJECTIVE: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val(158)Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). METHOD: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss-Durkee-Hostility Inventory (BDHI). RESULTS: Childhood sexual abuse was associated with lower BDHI sum score (P = 0.003). In COMT Val(158)Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (P < 0.05). CONCLUSION: This study analyzing a specific gene x environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMT Val(158)Val genotype on the relation between SLEs and impulsive aggression.
OBJECTIVE: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMTVal(158)Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). METHOD: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss-Durkee-Hostility Inventory (BDHI). RESULTS:Childhood sexual abuse was associated with lower BDHI sum score (P = 0.003). In COMTVal(158)Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (P < 0.05). CONCLUSION: This study analyzing a specific gene x environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMTVal(158)Val genotype on the relation between SLEs and impulsive aggression.
Authors: John M Myrga; Shannon B Juengst; Michelle D Failla; Yvette P Conley; Patricia M Arenth; Anthony A Grace; Amy K Wagner Journal: Neurorehabil Neural Repair Date: 2016-05-06 Impact factor: 3.919
Authors: Anahita Bassir Nia; Matthew C Eveleth; Jonathan M Gabbay; Yonis J Hassan; Bosi Zhang; M Mercedes Perez-Rodriguez Journal: Curr Opin Psychol Date: 2017-09-12
Authors: Jorge Lopez-Castroman; Nadine Melhem; Boris Birmaher; Laurence Greenhill; David Kolko; Barbara Stanley; Jamie Zelazny; Beth Brodsky; Rebeca Garcia-Nieto; Ainsley K Burke; J John Mann; David A Brent; Maria A Oquendo Journal: World Psychiatry Date: 2013-06 Impact factor: 49.548