Literature DB >> 19904787

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

Christelle Hureau1, Yannick Coppel, Pierre Dorlet, Pier Lorenzo Solari, Stéphanie Sayen, Emmanuel Guillon, Laurent Sabater, Peter Faller.   

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Year:  2009        PMID: 19904787     DOI: 10.1002/anie.200904512

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN: 1433-7851            Impact factor:   15.336


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  26 in total

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4.  Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.

Authors:  Byong-kyu Shin; Sunil Saxena
Journal:  J Phys Chem A       Date:  2011-04-14       Impact factor: 2.781

5.  Inhibition of Aβ42 peptide aggregation by a binuclear ruthenium(II)-platinum(II) complex: Potential for multi-metal organometallics as anti-amyloid agents.

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Review 6.  Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.

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7.  The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques.

Authors:  Dianlu Jiang; Lin Zhang; Gian Paola G Grant; Christopher G Dudzik; Shu Chen; Sveti Patel; Yuanqiang Hao; Glenn L Millhauser; Feimeng Zhou
Journal:  Biochemistry       Date:  2013-01-11       Impact factor: 3.162

Review 8.  Alzheimer's disease & metals: therapeutic opportunities.

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9.  Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-beta copper complex follow a preorganization mechanism.

Authors:  Véronique Balland; Christelle Hureau; Jean-Michel Savéant
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-21       Impact factor: 11.205

Review 10.  Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.

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Journal:  Chem Rev       Date:  2010-08-11       Impact factor: 60.622

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