Literature DB >> 19900758

Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.

Elizabeth Brandon-Warner1, James A Sugg, Laura W Schrum, Iain H McKillop.   

Abstract

Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture. 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19900758      PMCID： PMC3099213          DOI： 10.1016/j.canlet.2009.10.004

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  45 in total

1.  Assessing bioflavonoids as regulators of NF-kappa B activity and inflammatory gene expression in mammalian cells.

Authors:  C Saliou; G Valacchi; G Rimbach
Journal:  Methods Enzymol       Date:  2001       Impact factor: 1.600

2.  Inhibition of alcohol dehydrogenase blocks enhanced Gi-protein expression following ethanol treatment in experimental hepatocellular carcinoma in vitro.

Authors:  S J Kovach; J V Sitzmann; I H McKillop
Journal:  Eur J Gastroenterol Hepatol       Date:  2001-10       Impact factor: 2.566

3.  Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

Authors:  S K Manna; A Mukhopadhyay; N T Van; B B Aggarwal
Journal:  J Immunol       Date:  1999-12-15       Impact factor: 5.422

Review 4.  Multitargeted therapy of cancer by silymarin.

Authors:  Kumaraguruparan Ramasamy; Rajesh Agarwal
Journal:  Cancer Lett       Date:  2008-05-09       Impact factor: 8.679

5.  Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.

Authors:  Rana P Singh; Mallikarjuna Gu; Rajesh Agarwal
Journal:  Cancer Res       Date:  2008-03-15       Impact factor: 12.701

Review 6.  S-Adenosylmethionine in cell growth, apoptosis and liver cancer.

Authors:  Shelly C Lu; José M Mato
Journal:  J Gastroenterol Hepatol       Date:  2008-03       Impact factor: 4.029

7.  The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer.

Authors:  Wojciech Jelski; Bogdan Zalewski; Maciej Szmitkowski
Journal:  Dig Dis Sci       Date:  2008-01-26       Impact factor: 3.199

8.  S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model.

Authors:  Amel Karaa; Kyle J Thompson; Iain H McKillop; Mark G Clemens; Laura W Schrum
Journal:  Shock       Date:  2008-08       Impact factor: 3.454

Review 9.  Inflammatory pathways in liver homeostasis and liver injury.

Authors:  Frank Tacke; Tom Luedde; Christian Trautwein
Journal:  Clin Rev Allergy Immunol       Date:  2009-02       Impact factor: 10.817

Review 10.  Influence of alcohol and gender on immune response.

Authors:  Elizabeth J Kovacs; Kelly A N Messingham
Journal:  Alcohol Res Health       Date:  2002
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  16 in total

Review 1.  Targeting collagen expression in alcoholic liver disease.

Authors:  Kyle J Thompson; Iain H McKillop; Laura W Schrum
Journal:  World J Gastroenterol       Date:  2011-05-28       Impact factor: 5.742

2.  Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis.

Authors:  Elizabeth Brandon-Warner; Tracy L Walling; Laura W Schrum; Iain H McKillop
Journal:  Alcohol Clin Exp Res       Date:  2011-10-21       Impact factor: 3.455

3.  Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury.

Authors:  Min Wang; Yu-Jiao Li; Yi Ding; Hui-Nan Zhang; Ting Sun; Kun Zhang; Le Yang; Yan-Yan Guo; Shui-Bing Liu; Ming-Gao Zhao; Yu-Mei Wu
Journal:  Mol Neurobiol       Date:  2015-01-07       Impact factor: 5.590

4.  Diet-induced obesity and ethanol impair progression of hepatocellular carcinoma in a mouse mesenteric vein injection model.

Authors:  Kyle J Thompson; Ryan Z Swan; David A Iannitti; Iain H McKillop; David Sindram
Journal:  Surg Endosc       Date:  2012-07-18       Impact factor: 4.584

Review 5.  Role of alcohol in the development and progression of hepatocellular carcinoma.

Authors:  Iain H McKillop; Laura W Schrum; Kyle J Thompson
Journal:  Hepat Oncol       Date:  2015-11-30

6.  Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.

Authors:  Mohadeseh Dastpeyman; Nasrin Motamed; Kayhan Azadmanesh; Ehsan Mostafavi; Vahid Kia; Ali Jahanian-Najafabadi; Mohammad Ali Shokrgozar
Journal:  Med Oncol       Date:  2011-11-19       Impact factor: 3.064

7.  Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance.

Authors:  Anika Mann; Thomas Pelz; Knut Rennert; Alexander Mosig; Michael Decker; Amelie Lupp
Journal:  Hum Cell       Date:  2017-05-19       Impact factor: 4.174

8.  Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma.

Authors:  Eugene Sokolov; David A Iannitti; Laura W Schrum; Iain H McKillop
Journal:  Cell Signal       Date:  2011-05-18       Impact factor: 4.315

9.  Alcohol induces liver neoplasia in a novel alcohol-preferring rat model.

Authors:  Michele T Yip-Schneider; Courtney J Doyle; Iain H McKillop; Sabrina C Wentz; Elizabeth Brandon-Warner; Jesus M Matos; Kumaresan Sandrasegaran; Romil Saxena; Matthew E Hennig; Huangbing Wu; Joshua A Waters; Patrick J Klein; Janice C Froehlich; C Max Schmidt
Journal:  Alcohol Clin Exp Res       Date:  2011-07-25       Impact factor: 3.455

10.  Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.

Authors:  Elizabeth Brandon-Warner; Ashley L Eheim; David M Foureau; Tracy L Walling; Laura W Schrum; Iain H McKillop
Journal:  Cancer Lett       Date:  2012-08-01       Impact factor: 8.679
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