Literature DB >> 19898855

Urine toxicology screening in Austrian trauma patients: a prospective study.

Markus Figl1, Linda E Pelinka, Patrick Weninger, Christoph Walchetseder, Walter Mauritz, Harald Hertz, Albert Kroepfl, Robert Schmidhammer, Walter Buchinger, Heinz Redl.   

Abstract

INTRODUCTION: The question as to whether the patient consumed drugs prior to the trauma and which drugs were consumed, is of prime importance for the anesthesia required during surgery. However, many patients are unwilling or unable (including those with multiple trauma or impaired consciousness, or unconscious patients) to answer this question. The purpose of our prospective multicenter study was to collect data about drug consumption in Austria to determine whether drugs are identifiable in the urine of recently injured individuals and to establish the types of drugs consumed.
MATERIALS AND METHODS: This prospective study included severely and moderately injured patients admitted to the Lorenz Boehler Trauma Hospital (Vienna, Austria), the Trauma Hospital Linz (Linz, Austria) and the Department of Trauma Surgery of the General Hospital Horn (Horn, Austria) during an 18-month period (October 2003-March 2005). All patients were suffering from injuries urgently requiring surgery. Urine samples were gained from all patients immediately after admission. Urinary samples were tested by Immuno-Assay (Triage 8 Immuno-Assay, Biosite, San Diego, USA). Urine samples were screened simultaneously for opiates, methadone, cocaine, barbiturates, amphetamines, cannabinoids, benzodiazepines and tricyclic antidepressants.
RESULTS: Our prospective study included a total of 664 patients (320 from Vienna, 193 from the city of Linz, and 151 from Horn). Six hundred and forty-two patients were moderately injured (ISS < 16), suffering mostly from injuries to the extremities (504 patients) and 22 patients were severely injured (ISS > 16). Of the 664 patients, 178 (26.8%) tested positive for one or more drugs. The drugs most commonly detected were benzodiazepines (111 patients, 16.7%), cannabinoides (39 patients, 6%), tricyclic antidepressants (28, 4.2%) and opiates (26, 3.9%).
CONCLUSION: Drug use is widespread in patients presenting to urban trauma centers in Austria. Physicians should maintain a high index of suspicion that their patients may be intoxicated and should perform drug testing routinely.

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Year:  2009        PMID: 19898855     DOI: 10.1007/s00402-009-0995-5

Source DB:  PubMed          Journal:  Arch Orthop Trauma Surg        ISSN: 0936-8051            Impact factor:   3.067


  3 in total

1.  Prevalence of cocaine and derivatives in blood and urine samples of trauma patients and correlation with injury severity: a prospective observational study.

Authors:  K D Oliveira; G P Fraga; E C E Baracat; A M Morcillo; R Lanaro; J L Costa; E M Capitani; F Bucaretchi; A I Ferreira Filho; V C Gimenes; R C S de Azevedo
Journal:  Eur J Trauma Emerg Surg       Date:  2017-11-07       Impact factor: 3.693

2.  A Ten year review of alcohol use and major trauma in a Canadian province: still a major problem.

Authors:  Jessica McKee; Sandy L Widder; J Damian Paton-Gay; Andrew W Kirkpatrick; Paul Engels
Journal:  J Trauma Manag Outcomes       Date:  2016-01-21

3.  Are Intoxicated Trauma Patients at an Increased Risk for Intraoperative Anesthetic Complications? A Retrospective Study.

Authors:  Brian D Wolf; Swapna Munnangi; Raymond Pesso; Charles McCahery; Madhu Oad
Journal:  Anesthesiol Res Pract       Date:  2020-03-01
  3 in total

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