| Literature DB >> 19896944 |
Emmanuelle Schmitt1, Marie Naveau, Yves Mechulam.
Abstract
Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.Entities:
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Year: 2010 PMID: 19896944 DOI: 10.1016/j.febslet.2009.11.002
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124