Literature DB >> 19896728

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.

Laura Jean Bierut1.   

Abstract

Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health. 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19896728      PMCID： PMC2993565          DOI： 10.1016/j.tips.2009.10.004

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  38 in total

1.  Potential for genetics to promote public health: genetics research on smoking suggests caution about expectations.

Authors:  Chris Carlsten; Wylie Burke
Journal:  JAMA       Date:  2006-11-22       Impact factor: 56.272

2.  Genetic research and smoking behavior.

Authors:  Laura Jean Bierut; Joseph F Cubells; William G Iacono; Ming D Li; Pamela A F Madden; Elliot C Nelson; Jonathan D Pollock; Joni L Rutter; Gary E Swan; Michael Vanyukov
Journal:  JAMA       Date:  2007-02-28       Impact factor: 56.272

Review 3.  The genetics of nicotine dependence.

Authors:  Ming D Li
Journal:  Curr Psychiatry Rep       Date:  2006-04       Impact factor: 5.285

4.  Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

Authors:  W Berrettini; X Yuan; F Tozzi; K Song; C Francks; H Chilcoat; D Waterworth; P Muglia; V Mooser
Journal:  Mol Psychiatry       Date:  2008-01-29       Impact factor: 15.992

5.  Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

Authors:  Christopher I Amos; Xifeng Wu; Peter Broderick; Ivan P Gorlov; Jian Gu; Timothy Eisen; Qiong Dong; Qing Zhang; Xiangjun Gu; Jayaram Vijayakrishnan; Kate Sullivan; Athena Matakidou; Yufei Wang; Gordon Mills; Kimberly Doheny; Ya-Yu Tsai; Wei Vivien Chen; Sanjay Shete; Margaret R Spitz; Richard S Houlston
Journal:  Nat Genet       Date:  2008-04-02       Impact factor: 38.330

6.  Tobacco use among adults--United States, 2005.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2006-10-27       Impact factor: 17.586

7.  Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Authors:  Scott F Saccone; Anthony L Hinrichs; Nancy L Saccone; Gary A Chase; Karel Konvicka; Pamela A F Madden; Naomi Breslau; Eric O Johnson; Dorothy Hatsukami; Ovide Pomerleau; Gary E Swan; Alison M Goate; Joni Rutter; Sarah Bertelsen; Louis Fox; Douglas Fugman; Nicholas G Martin; Grant W Montgomery; Jen C Wang; Dennis G Ballinger; John P Rice; Laura Jean Bierut
Journal:  Hum Mol Genet       Date:  2006-11-29       Impact factor: 6.150

8.  A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

Authors:  Rayjean J Hung; James D McKay; Valerie Gaborieau; Paolo Boffetta; Mia Hashibe; David Zaridze; Anush Mukeria; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Chu Chen; Gary Goodman; John K Field; Triantafillos Liloglou; George Xinarianos; Adrian Cassidy; John McLaughlin; Geoffrey Liu; Steven Narod; Hans E Krokan; Frank Skorpen; Maiken Bratt Elvestad; Kristian Hveem; Lars Vatten; Jakob Linseisen; Françoise Clavel-Chapelon; Paolo Vineis; H Bas Bueno-de-Mesquita; Eiliv Lund; Carmen Martinez; Sheila Bingham; Torgny Rasmuson; Pierre Hainaut; Elio Riboli; Wolfgang Ahrens; Simone Benhamou; Pagona Lagiou; Dimitrios Trichopoulos; Ivana Holcátová; Franco Merletti; Kristina Kjaerheim; Antonio Agudo; Gary Macfarlane; Renato Talamini; Lorenzo Simonato; Ray Lowry; David I Conway; Ariana Znaor; Claire Healy; Diana Zelenika; Anne Boland; Marc Delepine; Mario Foglio; Doris Lechner; Fumihiko Matsuda; Helene Blanche; Ivo Gut; Simon Heath; Mark Lathrop; Paul Brennan
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

9.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

Authors:  Thorgeir E Thorgeirsson; Frank Geller; Patrick Sulem; Thorunn Rafnar; Anna Wiste; Kristinn P Magnusson; Andrei Manolescu; Gudmar Thorleifsson; Hreinn Stefansson; Andres Ingason; Simon N Stacey; Jon T Bergthorsson; Steinunn Thorlacius; Julius Gudmundsson; Thorlakur Jonsson; Margret Jakobsdottir; Jona Saemundsdottir; Olof Olafsdottir; Larus J Gudmundsson; Gyda Bjornsdottir; Kristleifur Kristjansson; Halla Skuladottir; Helgi J Isaksson; Tomas Gudbjartsson; Gregory T Jones; Thomas Mueller; Anders Gottsäter; Andrea Flex; Katja K H Aben; Femmie de Vegt; Peter F A Mulders; Dolores Isla; Maria J Vidal; Laura Asin; Berta Saez; Laura Murillo; Thorsteinn Blondal; Halldor Kolbeinsson; Jon G Stefansson; Ingunn Hansdottir; Valgerdur Runarsdottir; Roberto Pola; Bengt Lindblad; Andre M van Rij; Benjamin Dieplinger; Meinhard Haltmayer; Jose I Mayordomo; Lambertus A Kiemeney; Stefan E Matthiasson; Hogni Oskarsson; Thorarinn Tyrfingsson; Daniel F Gudbjartsson; Jeffrey R Gulcher; Steinn Jonsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

10.  A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

Authors:  Robert B Weiss; Timothy B Baker; Dale S Cannon; Andrew von Niederhausern; Diane M Dunn; Nori Matsunami; Nanda A Singh; Lisa Baird; Hilary Coon; William M McMahon; Megan E Piper; Michael C Fiore; Mary Beth Scholand; John E Connett; Richard E Kanner; Lorise C Gahring; Scott W Rogers; John R Hoidal; Mark F Leppert
Journal:  PLoS Genet       Date:  2008-07-11       Impact factor: 5.917
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  55 in total

Review 1.  The co-occurring use and misuse of cannabis and tobacco: a review.

Authors:  Arpana Agrawal; Alan J Budney; Michael T Lynskey
Journal:  Addiction       Date:  2012-04-17       Impact factor: 6.526

Review 2.  Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.

Authors:  Shaolin Wang; Zhongli Yang; Jennie Z Ma; Thomas J Payne; Ming D Li
Journal:  Mol Neurobiol       Date:  2013-08-30       Impact factor: 5.590

3.  Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.

Authors:  Jenni Hällfors; Anu Loukola; Janne Pitkäniemi; Ulla Broms; Satu Männistö; Veikko Salomaa; Markku Heliövaara; Terho Lehtimäki; Olli Raitakari; Pamela Af Madden; Andrew C Heath; Grant W Montgomery; Nicholas G Martin; Tellervo Korhonen; Jaakko Kaprio
Journal:  Int J Mol Epidemiol Genet       Date:  2013-06-25

Review 4.  Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health.

Authors:  Cindy T McEvoy; Eliot R Spindel
Journal:  Paediatr Respir Rev       Date:  2016-08-19       Impact factor: 2.726

5.  Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.

Authors:  Cindy L Ehlers; Ian R Gizer; David A Gilder; Kirk C Wilhelmsen
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2011-08-02       Impact factor: 3.568

6.  Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands.

Authors:  Caroline Ray; Erik J Soderblom; Yushi Bai; F Ivy Carroll; Marc G Caron; Larry S Barak
Journal:  ACS Chem Biol       Date:  2017-01-24       Impact factor: 5.100

7.  Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment.

Authors:  Junran Cao; Tanseli Nesil; Shaolin Wang; Sulie L Chang; Ming D Li
Journal:  J Neurovirol       Date:  2016-04-07       Impact factor: 2.643

8.  The case-only independence assumption: associations between genetic polymorphisms and smoking among controls in two population-based studies.

Authors:  M Elizabeth Hodgson; Andrew F Olshan; Kari E North; Charles L Poole; Donglin Zeng; Chiu-Kit Tse; Tope O Keku; Joseph Galanko; Robert Sandler; Robert C Millikan
Journal:  Int J Mol Epidemiol Genet       Date:  2012-11-15

9.  Effects of intravenous nicotine on prepulse inhibition in smokers and non-smokers: relationship with familial smoking.

Authors:  David J Drobes; David A MacQueen; Melissa D Blank; Michael E Saladin; Robert J Malcolm
Journal:  Psychopharmacology (Berl)       Date:  2013-04-28       Impact factor: 4.530

10.  Genetic Endowments and Wealth Inequality.

Authors:  Daniel Barth; Nicholas W Papageorge; Kevin Thom
Journal:  J Polit Econ       Date:  2020-04
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