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Literature DB >> 19896366

The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation.

Riccardo Baron¹, J Andrew McCammon, Andrea Mattevi.

Abstract

Oxygen biocatalysis and regulation is crucial to a variety of biochemical processes in nature. Oxygen-binding proteins cover only a limited part of oxygen biocatalysis, which involves numerous examples of oxygen-consuming biocatalysts with low oxygen affinities. The integration of experiments with powerful biomolecular simulation opens appealing possibilities to investigate crucial questions on the fascinating relationship between enzyme dynamics and oxygen biocatalysis in new protein structures.

Entities: Chemical

Mesh：

Substances：
Enzymes
Oxygen

Year: 2009 PMID： 19896366 DOI： 10.1016/j.sbi.2009.10.003

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

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Cited

14 in total

1. Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation.

Authors: Po-hung Wang; Jochen Blumberger
Journal: Proc Natl Acad Sci U S A Date: 2012-04-09 Impact factor: 11.205

2. Structural characterization of mutations at the oxygen activation site in monomeric sarcosine oxidase .

Authors: Marilyn Schuman Jorns; Zhi-Wei Chen; F Scott Mathews
Journal: Biochemistry Date: 2010-05-04 Impact factor: 3.162

3. Applicability of fluorescence-based sensors to the determination of kinetic parameters for O₂ in oxygenases.

Authors: Natali V Di Russo; Steven D Bruner; Adrian E Roitberg
Journal: Anal Biochem Date: 2015-01-28 Impact factor: 3.365

Review 4. Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation.

Authors: J V Vermaas; N Trebesch; C G Mayne; S Thangapandian; M Shekhar; P Mahinthichaichan; J L Baylon; T Jiang; Y Wang; M P Muller; E Shinn; Z Zhao; P-C Wen; E Tajkhorshid
Journal: Methods Enzymol Date: 2016-07-11 Impact factor: 1.600

5. Single turnover kinetics of tryptophan hydroxylase: evidence for a new intermediate in the reaction of the aromatic amino acid hydroxylases.

Authors: Jorge Alex Pavon; Bekir Eser; Michaela T Huynh; Paul F Fitzpatrick
Journal: Biochemistry Date: 2010-09-07 Impact factor: 3.162

The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation.

1. Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation.

2. Structural characterization of mutations at the oxygen activation site in monomeric sarcosine oxidase .

3. Applicability of fluorescence-based sensors to the determination of kinetic parameters for O₂ in oxygenases.

Review 4. Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation.

5. Single turnover kinetics of tryptophan hydroxylase: evidence for a new intermediate in the reaction of the aromatic amino acid hydroxylases.

6. Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.

7. Identification of Mutational Hot Spots for Substrate Diffusion: Application to Myoglobin.

8. Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.

9. Oxygen Pathways and Allostery in Monomeric Sarcosine Oxidase via Single-Sweep Free-Energy Reconstruction.

Review 10. MICAL, the flavoenzyme participating in cytoskeleton dynamics.