Literature DB >> 19896247

Poly(ethylene glycol) (PEG-400) as an alternative reaction solvent for the synthesis of some new 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazolines and their in vitro antimicrobial evaluation.

Bhaskar S Dawane1, Shankaraiah G Konda, Gajanan G Mandawad, Baseer M Shaikh.   

Abstract

Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazoline derivatives were prepared by the base catalyzed treatment of appropriate chalcones with 4-(4'-chlorophenyl)-2-hydrazino-thiazole in poly (ethylene glycol) (PEG-400) as an alternative reaction solvent. All the synthesized compounds were tested for their antimicrobial activities against Escherichia coli (MTCC 2939), Salmonella typhi (MTCC 98), Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Aspergillus niger (MTCC 281), Trichoderma viridae (MTCC 167), Penicillium chrysogenum (MTCC 160), Fusarium moniliforme (MTCC 156) and Candida albicans (MTCC 183). Most of the compounds showed potent antibacterial and antifungal activity. Copyright 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 19896247     DOI： 10.1016/j.ejmech.2009.10.015

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  Synthesis and antimicrobial evaluation of certain novel thiazoles.

Authors:  Meesaraganda Sreedevi; Aluru Raghavendra Guru Prasad; Yadati Narasimha Spoorthy; Lakshmana Rao Krishna Rao Ravindranath
Journal:  Adv Pharm Bull       Date:  2013-02-07

2.  Synthesis and Anti-Cancer Activity of New Pyrazolinyl-Indole Derivatives: Pharmacophoric Interactions and Docking Studies for Identifying New EGFR Inhibitors.

Authors:  Habibullah Khalilullah; Deepak K Agarwal; Mohamed J Ahsan; Surender S Jadav; Hamdoon A Mohammed; Masood Alam Khan; Salman A A Mohammed; Riaz Khan
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

3.  In-silico docking based design and synthesis of [1H,3H] imidazo[4,5-b] pyridines as lumazine synthase inhibitors for their effective antimicrobial activity.

Authors:  Sunil L Harer; Manish S Bhatia
Journal:  J Pharm Bioallied Sci       Date:  2014-10

4.  Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents.

Authors:  Sraa Abu-Melha; Mastoura M Edrees; Heba H Salem; Nabila A Kheder; Sobhi M Gomha; Mohamad R Abdelaziz
Journal:  Molecules       Date:  2019-02-01       Impact factor: 4.411

5.  Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.

Authors:  Yahia N Mabkhot; Mohammed M Alharbi; Salim S Al-Showiman; Hazem A Ghabbour; Nabila A Kheder; Saied M Soliman; Wolfgang Frey
Journal:  Chem Cent J       Date:  2018-05-11       Impact factor: 4.215

6.  Eco-Friendly Synthesis, Characterization and Biological Evaluation of Some Novel Pyrazolines Containing Thiazole Moiety as Potential Anticancer and Antimicrobial Agents.

Authors:  Mastoura M Edrees; Sraa Abu- Melha; Amirah M Saad; Nabila A Kheder; Sobhi M Gomha; Zeinab A Muhammad
Journal:  Molecules       Date:  2018-11-14       Impact factor: 4.411
  6 in total

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