Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Kirkwood-Buff theory of molecular and protein association, aggregation, and cellular crowding.

Literature DB >> 19894976

Kirkwood-Buff theory of molecular and protein association, aggregation, and cellular crowding.

Abstract

An analysis of the effect of a cosolvent on the association of a solute in solution using the Kirkwood-Buff theory of solutions is presented. The approach builds on the previous results of Ben-Naim by extending the range of applicability to include any number of components at finite concentrations in both closed and semiopen systems. The derived expressions, which are exact, provide a foundation for the analysis and rationalization of cosolvent effects on molecular and biomolecular equilibria including protein association, aggregation, and cellular crowding. A slightly different view of cellular crowding is subsequently obtained. In particular, it is observed that the addition of large cosolvents still favors the associated form even when traditional excluded volume effects are absent.

Entities: Chemical

Mesh：

Substances：
Proteins
Solvents

Year: 2009 PMID： 19894976 PMCID： PMC2780464 DOI： 10.1063/1.3253299

Source DB: PubMed Journal: J Chem Phys ISSN： 0021-9606 Impact factor: 3.488

39 in total

Review 1. Protein folding and misfolding.

Authors: Christopher M Dobson
Journal: Nature Date: 2003-12-18 Impact factor: 49.962

2. Estimating hydration changes upon biomolecular reactions from osmotic stress, high pressure, and preferential hydration experiments.

Authors: Seishi Shimizu
Journal: Proc Natl Acad Sci U S A Date: 2004-01-19 Impact factor: 11.205

3. Model for the role of macromolecular crowding in regulation of cellular volume.

Authors: A P Minton; G C Colclasure; J C Parker
Journal: Proc Natl Acad Sci U S A Date: 1992-11-01 Impact factor: 11.205

4. Aqueous urea solution destabilizes Abeta(16-22) oligomers.

Authors: D K Klimov; John E Straub; D Thirumalai
Journal: Proc Natl Acad Sci U S A Date: 2004-10-01 Impact factor: 11.205

5. Protein volume changes on cosolvent denaturation.

Authors: Paul E Smith
Journal: Biophys Chem Date: 2005-03-01 Impact factor: 2.352

Review 6. Macromolecular crowding and its potential impact on nuclear function.

Authors: Karsten Richter; Michelle Nessling; Peter Lichter
Journal: Biochim Biophys Acta Date: 2008-07-30

7. Effect of mixed macromolecular crowding agents on protein folding.

Authors: Huan-Xiang Zhou
Journal: Proteins Date: 2008-09

Review 8. Protein denaturation. C. Theoretical models for the mechanism of denaturation.

Authors: C Tanford
Journal: Adv Protein Chem Date: 1970

9. Thermodynamics of the denaturation of lysozyme by guanidine hydrochloride. II. Dependence on denaturant concentration at 25 degrees.

Authors: K C Aune; C Tanford
Journal: Biochemistry Date: 1969-11 Impact factor: 3.162

10. Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding.

Authors: J K Myers; C N Pace; J M Scholtz
Journal: Protein Sci Date: 1995-10 Impact factor: 6.725

13 in total

1. Kirkwood-Buff integrals for ideal solutions.

Authors: Elizabeth A Ploetz; Nikolaos Bentenitis; Paul E Smith
Journal: J Chem Phys Date: 2010-04-28 Impact factor: 3.488

2. Local Fluctuations in Solution: Theory and Applications.

Authors: Elizabeth A Ploetz; Paul E Smith
Journal: Adv Chem Phys Date: 2013 Impact factor: 1.000

3. Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation.

Authors: Alex S Holehouse; Kanchan Garai; Nicholas Lyle; Andreas Vitalis; Rohit V Pappu
Journal: J Am Chem Soc Date: 2015-02-23 Impact factor: 15.419

Kirkwood-Buff theory of molecular and protein association, aggregation, and cellular crowding.

Review 1. Protein folding and misfolding.

2. Estimating hydration changes upon biomolecular reactions from osmotic stress, high pressure, and preferential hydration experiments.

3. Model for the role of macromolecular crowding in regulation of cellular volume.

4. Aqueous urea solution destabilizes Abeta(16-22) oligomers.

5. Protein volume changes on cosolvent denaturation.

Review 6. Macromolecular crowding and its potential impact on nuclear function.

7. Effect of mixed macromolecular crowding agents on protein folding.

Review 8. Protein denaturation. C. Theoretical models for the mechanism of denaturation.

9. Thermodynamics of the denaturation of lysozyme by guanidine hydrochloride. II. Dependence on denaturant concentration at 25 degrees.

10. Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding.

1. Kirkwood-Buff integrals for ideal solutions.

2. Local Fluctuations in Solution: Theory and Applications.

3. Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation.

4. Power-law dependence of the melting temperature of ubiquitin on the volume fraction of macromolecular crowders.

5. Fluctuation theory of molecular association and conformational equilibria.

6. Local fluctuations in solution mixtures.

7. Kirkwood-Buff integrals for hard-core Yukawa fluids.

8. Theory and Simulation of Multicomponent Osmotic Systems.

Review 9. Reaching new levels of realism in modeling biological macromolecules in cellular environments.

10. Crowding alone cannot account for cosolute effect on amyloid aggregation.