Literature DB >> 19894196

The synthesis of therapeutic locked nucleos(t)ides.

Chuanzheng Zhou1, Jyoti Chattopadhyaya.   

Abstract

This review highlights progress made during the past 2 to 3 years in the field of therapeutic locked nucleos(t)ides. Synthetic strategies to construct the conformationally locked nucleos(t)ides, their properties and potential therapeutic applications as antiviral compounds, and modified oligonucleotides to modulate antisense and RNAi properties are described.

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Year:  2009        PMID： 19894196

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  9 in total

1.  An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

Authors:  Punit P Seth; Charles R Allerson; Andres Berdeja; Andrew Siwkowski; Pradeep S Pallan; Hans Gaus; Thazha P Prakash; Andrew T Watt; Martin Egli; Eric E Swayze
Journal:  J Am Chem Soc       Date:  2010-10-27       Impact factor: 15.419

Review 2.  Functional Xeno Nucleic Acids for Biomedical Application.

Authors:  Tingting Tu; Shuangyan Huan; Guoliang Ke; Xiaobing Zhang
Journal:  Chem Res Chin Univ       Date:  2022-07-05       Impact factor: 2.726

3.  N,3'-cyclo-5'-O-Cyano-methyl-thymidine.

Authors:  Jingbo Sun; Kun Yang; Ronghui Duan; Jinchang Wu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

4.  The RNA Modification Database, RNAMDB: 2011 update.

Authors:  William A Cantara; Pamela F Crain; Jef Rozenski; James A McCloskey; Kimberly A Harris; Xiaonong Zhang; Franck A P Vendeix; Daniele Fabris; Paul F Agris
Journal:  Nucleic Acids Res       Date:  2010-11-10       Impact factor: 16.971

5.  A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

Authors:  Stefano D'Errico; Giorgia Oliviero; Nicola Borbone; Jussara Amato; Daniele D'Alonzo; Vincenzo Piccialli; Luciano Mayol; Gennaro Piccialli
Journal:  Molecules       Date:  2012-11-02       Impact factor: 4.411

Review 6.  Convertible and Constrained Nucleotides: The 2'-Deoxyribose 5'-C-Functionalization Approach, a French Touch.

Authors:  Crystalle Chardet; Corinne Payrastre; Béatrice Gerland; Jean-Marc Escudier
Journal:  Molecules       Date:  2021-09-30       Impact factor: 4.411

Review 7.  Nucleic Acids and Their Analogues for Biomedical Applications.

Authors:  Fei Wang; Pan Li; Hoi Ching Chu; Pik Kwan Lo
Journal:  Biosensors (Basel)       Date:  2022-02-04

8.  Dioxaphosphorinane-constrained nucleic Acid dinucleotides as tools for structural tuning of nucleic acids.

Authors:  Dan-Andrei Catana; Brice-Loïc Renard; Marie Maturano; Corinne Payrastre; Nathalie Tarrat; Jean-Marc Escudier
Journal:  J Nucleic Acids       Date:  2012-10-24

9.  Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides.

Authors:  Yogesh Yadav; Deepti Sharma; Kumar Kaushik; Vineet Kumar; Amitabh Jha; Ashok K Prasad; Christophe Len; Sanjay V Malhotra; Jesper Wengel; Virinder S Parmar
Journal:  Molecules       Date:  2019-10-30       Impact factor: 4.411
  9 in total

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