| Literature DB >> 19892987 |
C M Wade1, E Giulotto, S Sigurdsson, M Zoli, S Gnerre, F Imsland, T L Lear, D L Adelson, E Bailey, R R Bellone, H Blöcker, O Distl, R C Edgar, M Garber, T Leeb, E Mauceli, J N MacLeod, M C T Penedo, J M Raison, T Sharpe, J Vogel, L Andersson, D F Antczak, T Biagi, M M Binns, B P Chowdhary, S J Coleman, G Della Valle, S Fryc, G Guérin, T Hasegawa, E W Hill, J Jurka, A Kiialainen, G Lindgren, J Liu, E Magnani, J R Mickelson, J Murray, S G Nergadze, R Onofrio, S Pedroni, M F Piras, T Raudsepp, M Rocchi, K H Røed, O A Ryder, S Searle, L Skow, J E Swinburne, A C Syvänen, T Tozaki, S J Valberg, M Vaudin, J R White, M C Zody, E S Lander, K Lindblad-Toh.
Abstract
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.Entities:
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Year: 2009 PMID： 19892987 PMCID： PMC3785132 DOI： 10.1126/science.1178158
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728