BACKGROUND: the existence of a relationship among inflammation, high-density lipoprotein cholesterol (HDL-C) and physical function has been suggested. OBJECTIVE: the aim of the study is to investigate the possible interaction of HDL-C on inflammation and physical function. DESIGN: cross-sectional study. SETTING: town of Tuscania (Italy). SUBJECTS: all the 329 community-dwelling older persons aged > or =75 years (mean age 79.8 +/- 5.2 years, women 56.2%). METHODS: HDL-C, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Activities of daily living (ADL), instrumental ADL (IADL) and 4-m walking speed were assessed. Linear regression models were performed. RESULTS: given the multiple significant interactions, models were stratified according to HDL-C concentrations. In participants with normal HDL-C concentrations, only IL-6 showed a significant association with IADL (beta = -0.439, SE = 0.176, P = 0.01). In participants with low HDL-C concentrations, all three inflammatory biomarkers were significantly associated with 4-m walking speed and IADL. IL-6 was also significantly associated with ADL (beta = -0.755, SE = 0.259, P = 0.006), whereas borderline significances were reported for CRP and ESR. CONCLUSIONS: the association between inflammation and physical function is particularly enhanced in elders with low HDL-C concentrations. Though HDL-C may merely act as a wellbeing index, HDL-C concentrations should be considered in studies evaluating inflammation and physical function.
BACKGROUND: the existence of a relationship among inflammation, high-density lipoprotein cholesterol (HDL-C) and physical function has been suggested. OBJECTIVE: the aim of the study is to investigate the possible interaction of HDL-C on inflammation and physical function. DESIGN: cross-sectional study. SETTING: town of Tuscania (Italy). SUBJECTS: all the 329 community-dwelling older persons aged > or =75 years (mean age 79.8 +/- 5.2 years, women 56.2%). METHODS: HDL-C, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Activities of daily living (ADL), instrumental ADL (IADL) and 4-m walking speed were assessed. Linear regression models were performed. RESULTS: given the multiple significant interactions, models were stratified according to HDL-C concentrations. In participants with normal HDL-C concentrations, only IL-6 showed a significant association with IADL (beta = -0.439, SE = 0.176, P = 0.01). In participants with low HDL-C concentrations, all three inflammatory biomarkers were significantly associated with 4-m walking speed and IADL. IL-6 was also significantly associated with ADL (beta = -0.755, SE = 0.259, P = 0.006), whereas borderline significances were reported for CRP and ESR. CONCLUSIONS: the association between inflammation and physical function is particularly enhanced in elders with low HDL-C concentrations. Though HDL-C may merely act as a wellbeing index, HDL-C concentrations should be considered in studies evaluating inflammation and physical function.
Authors: L Ferrucci; T B Harris; J M Guralnik; R P Tracy; M C Corti; H J Cohen; B Penninx; M Pahor; R Wallace; R J Havlik Journal: J Am Geriatr Soc Date: 1999-06 Impact factor: 5.562
Authors: Matteo Cesari; Brenda W J H Penninx; Marco Pahor; Fulvio Lauretani; Anna Maria Corsi; G Rhys Williams; Jack M Guralnik; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2004-03 Impact factor: 6.053
Authors: Stephen D Anton; Adam J Woods; Tetso Ashizawa; Diana Barb; Thomas W Buford; Christy S Carter; David J Clark; Ronald A Cohen; Duane B Corbett; Yenisel Cruz-Almeida; Vonetta Dotson; Natalie Ebner; Philip A Efron; Roger B Fillingim; Thomas C Foster; David M Gundermann; Anna-Maria Joseph; Christy Karabetian; Christiaan Leeuwenburgh; Todd M Manini; Michael Marsiske; Robert T Mankowski; Heather L Mutchie; Michael G Perri; Sanjay Ranka; Parisa Rashidi; Bhanuprasad Sandesara; Philip J Scarpace; Kimberly T Sibille; Laurence M Solberg; Shinichi Someya; Connie Uphold; Stephanie Wohlgemuth; Samuel Shangwu Wu; Marco Pahor Journal: Ageing Res Rev Date: 2015-10-14 Impact factor: 10.895
Authors: Todd M Manini; Stephen D Anton; Daniel P Beavers; Jane A Cauley; Mark A Espeland; Roger A Fielding; Stephen B Kritchevsky; Christiaan Leeuwenburgh; Kristina H Lewis; Christine Liu; Mary M McDermott; Michael E Miller; Russell P Tracy; Jeremy D Walston; Barbara Radziszewska; Jane Lu; Cindy Stowe; Samuel Wu; Anne B Newman; Walter T Ambrosius; Marco Pahor Journal: J Am Geriatr Soc Date: 2017-07-22 Impact factor: 5.562
Authors: Erick Prado de Oliveira; Rodrigo Minoru Manda; Gabriel Augusto Torezan; José Eduardo Corrente; Roberto Carlos Burini Journal: Cholesterol Date: 2010-12-15