PRIMARY OBJECTIVE: To study the protective effect of resveratrol on endotoxemia-induced neurotoxicity. METHODS: Rats were pre-treated during 7 days with 20 mg kg(-1) body weight (b.w.) resveratrol and challenged with a single dose of lipopolysaccharide (LPS: 8 mg kg(-1) b.w.) for 24 hours. Brains were harvested to determine LPS-induced lipoperoxidation level, antioxidant enzyme activities, nitric monoxide (NO) and iron distribution as well as the impact of resveratrol on these parameters. RESULTS: Resveratrol counteracted LPS-induced brain malondialdehyde (MDA) level and antioxidant enzyme activities depletion as superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). Resveratrol also reversed LPS-induced brain and plasma NO elevation as well as iron sequestration from plasma to brain compartment. CONCLUSION: The data suggest that resveratrol is capable of alleviating LPS-induced neurotoxicity by a mechanism that may involve iron shuttling proteins.
PRIMARY OBJECTIVE: To study the protective effect of resveratrol on endotoxemia-induced neurotoxicity. METHODS:Rats were pre-treated during 7 days with 20 mg kg(-1) body weight (b.w.) resveratrol and challenged with a single dose of lipopolysaccharide (LPS: 8 mg kg(-1) b.w.) for 24 hours. Brains were harvested to determine LPS-induced lipoperoxidation level, antioxidant enzyme activities, nitric monoxide (NO) and iron distribution as well as the impact of resveratrol on these parameters. RESULTS:Resveratrol counteracted LPS-induced brain malondialdehyde (MDA) level and antioxidant enzyme activities depletion as superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). Resveratrol also reversed LPS-induced brain and plasma NO elevation as well as iron sequestration from plasma to brain compartment. CONCLUSION: The data suggest that resveratrol is capable of alleviating LPS-induced neurotoxicity by a mechanism that may involve iron shuttling proteins.
Authors: Jing Hua; Karen I Guerin; Jing Chen; Shaday Michán; Andreas Stahl; Nathan M Krah; Molly R Seaward; Roberta J Dennison; Aimee M Juan; Colman J Hatton; Przemyslaw Sapieha; David A Sinclair; Lois E H Smith Journal: Invest Ophthalmol Vis Sci Date: 2011-04-25 Impact factor: 4.799
Authors: M Larrosa; M Azorín-Ortuño; M J Yañez-Gascón; M T García-Conesa; F Tomás-Barberán; J C Espín Journal: Eur J Nutr Date: 2011-03-04 Impact factor: 5.614
Authors: M Xu; Z L Sulkowski; P Parekh; A Khan; T Chen; S Midha; T Iwasaki; N Shimokawa; N Koibuchi; A M Zavacki; E M Sajdel-Sulkowska Journal: Cerebellum Date: 2013-08 Impact factor: 3.847
Authors: Sigrid C Veasey; Jessica Lear; Yan Zhu; Judith B Grinspan; Dominic J Hare; Sihe Wang; Dustin Bunch; Philip A Doble; Stephen R Robinson Journal: Sleep Date: 2013-10-01 Impact factor: 5.849