| Literature DB >> 19889480 |
Grégory Spataro1, François Malecaze, Cédric-Olivier Turrin, Vincent Soler, Carine Duhayon, Pierre-Paul Elena, Jean-Pierre Majoral, Anne-Marie Caminade.
Abstract
New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits. Copyright 2009 Elsevier Masson SAS. All rights reserved.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19889480 DOI： 10.1016/j.ejmech.2009.10.017
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514