Literature DB >> 19884964

OPTIMIZATION OF A MICROFLUIDIC DEVICE FOR DIFFUSION-BASED EXTRACTION OF DMSO FROM A CELL SUSPENSION.

K K Fleming Glass1, E K Longmire, A Hubel.   

Abstract

This study considers the use of a two-stream microfluidic device for extraction of dimethyl sulphoxide (DMSO) from a cryopreserved cell suspension. The DMSO diffuses from a cell suspension stream into a neighboring wash stream flowing in parallel. The model of Fleming et al.[14] is employed to determine and discuss optimal geometry and operating conditions for a case requiring removal of 95% DMSO from suspension streams with volumetric flow rates up to 2.5 ml/min. The effects of Peclet number, flow rate fraction, and cell volume fraction are analyzed, and expansion of the analysis to other applications is discussed.

Entities:  

Year:  2008        PMID： 19884964      PMCID： PMC2621076          DOI： 10.1016/j.ijheatmasstransfer.2008.04.018

Source DB:  PubMed          Journal:  Int J Heat Mass Transf        ISSN： 0017-9310            Impact factor:   5.584


  14 in total

1.  A rapid diffusion immunoassay in a T-sensor.

Authors:  A Hatch; A E Kamholz; K R Hawkins; M S Munson; E A Schilling; B H Weigl; P Yager
Journal:  Nat Biotechnol       Date:  2001-05       Impact factor: 54.908

2.  Osmometric and permeability characteristics of human placental/umbilical cord blood CD34+ cells and their application to cryopreservation.

Authors:  E J Woods; J Liu; C W Derrow; F O Smith; D A Williams; J K Critser
Journal:  J Hematother Stem Cell Res       Date:  2000-04

Review 3.  Hematopoietic stem cell processing and cryopreservation.

Authors:  S D Rowley
Journal:  J Clin Apher       Date:  1992       Impact factor: 2.821

4.  A new automated cell washer device for thawed cord blood units.

Authors:  Cesare G Perotti; Claudia Del Fante; Gianluca Viarengo; Pietro Papa; Loretta Rocchi; Paola Bergamaschi; Laura Bellotti; Andrea Marchesi; Laura Salvaneschi
Journal:  Transfusion       Date:  2004-06       Impact factor: 3.157

5.  Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel.

Authors:  Jeremy J Hawkes; Robert W Barber; David R Emerson; W Terence Coakley
Journal:  Lab Chip       Date:  2004-09-27       Impact factor: 6.799

6.  Microfluidic diffusive filter for apheresis (leukapheresis).

Authors:  Palaniappan Sethu; Aaron Sin; Mehmet Toner
Journal:  Lab Chip       Date:  2005-11-11       Impact factor: 6.799

7.  Blood plasma separation in microfluidic channels using flow rate control.

Authors:  Sung Yang; Akif Undar; Jeffrey D Zahn
Journal:  ASAIO J       Date:  2005 Sep-Oct       Impact factor: 2.872

8.  Processing and storage of human bone marrow: a survey of current practices in North America.

Authors:  E M Areman; R A Sacher; H J Deeg
Journal:  Bone Marrow Transplant       Date:  1990-09       Impact factor: 5.483

9.  Numerical characterization of diffusion-based extraction in cell-laden flow through a microfluidic channel.

Authors:  K K Fleming; E K Longmire; A Hubel
Journal:  J Biomech Eng       Date:  2007-10       Impact factor: 2.097

10.  Cryopreservation and storage of human bone marrow: a survey of current practices.

Authors:  E M Areman; R A Sacher; H J Deeg
Journal:  Prog Clin Biol Res       Date:  1990
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  6 in total

1.  Mathematical model formulation and validation of water and solute transport in whole hamster pancreatic islets.

Authors:  James D Benson; Charles T Benson; John K Critser
Journal:  Math Biosci       Date:  2014-06-17       Impact factor: 2.144

2.  A numerical study on distributions during cryoprotectant loading caused by laminar flow in a microchannel.

Authors:  T Scherr; S Pursley; W T Monroe; K Nandakumar
Journal:  Biomicrofluidics       Date:  2013-03-11       Impact factor: 2.800

Review 3.  Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion.

Authors:  Z Shu; S Heimfeld; D Gao
Journal:  Bone Marrow Transplant       Date:  2013-09-30       Impact factor: 5.483

4.  Continuous removal of glycerol from frozen-thawed red blood cells in a microfluidic membrane device.

Authors:  Ratih E Lusianti; Adam Z Higgins
Journal:  Biomicrofluidics       Date:  2014-10-28       Impact factor: 2.800

5.  Influence of buoyancy-driven flow on mass transfer in a two-stream microfluidic channel: Introduction of cryoprotective agents into cell suspensions.

Authors:  Rohini Bala Chandran; Jennifer Reinhart; Erin Lemke; Allison Hubel
Journal:  Biomicrofluidics       Date:  2012-11-26       Impact factor: 2.800

Review 6.  Improving Cell Recovery: Freezing and Thawing Optimization of Induced Pluripotent Stem Cells.

Authors:  Markus Uhrig; Fernando Ezquer; Marcelo Ezquer
Journal:  Cells       Date:  2022-02-24       Impact factor: 6.600
  6 in total

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