ETHNOPHARMACOLOGICAL RELEVANCE: Grains of Paradise (Aframomum melegueta [Roscoe] K. Schum.) seeds are used in West Africa as a remedy for variety of ailments such as stomach ache, snakebite, diarrhea and they have reported anti-inflammatory properties. Additionally, the seeds contain gingerols and related compounds that may be useful against cardiovascular disease, diabetes, and inflammation. AIM OF STUDY: A 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats was conducted to evaluate the safety of a Grains of Paradise extract. MATERIALS AND METHODS: An ethanolic extract of the seeds was evaluated for toxicological effect on rats. RESULTS: A dose-related increase in absolute and relative liver weights was observed in males and females dosed with 450 and 1500 mg/kg. There was a corresponding increase in alkaline phosphatase with no signs of steatosis or cirrhosis. At the same doses, there was a significant decrease in blood glucose in male rats. CONCLUSIONS: This study shows that Grains of Paradise extract may be useful as a treatment for diabetes, however liver toxicity should be considered. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
ETHNOPHARMACOLOGICAL RELEVANCE: Grains of Paradise (Aframomum melegueta [Roscoe] K. Schum.) seeds are used in West Africa as a remedy for variety of ailments such as stomach ache, snakebite, diarrhea and they have reported anti-inflammatory properties. Additionally, the seeds contain gingerols and related compounds that may be useful against cardiovascular disease, diabetes, and inflammation. AIM OF STUDY: A 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats was conducted to evaluate the safety of a Grains of Paradise extract. MATERIALS AND METHODS: An ethanolic extract of the seeds was evaluated for toxicological effect on rats. RESULTS: A dose-related increase in absolute and relative liver weights was observed in males and females dosed with 450 and 1500 mg/kg. There was a corresponding increase in alkaline phosphatase with no signs of steatosis or cirrhosis. At the same doses, there was a significant decrease in blood glucose in male rats. CONCLUSIONS: This study shows that Grains of Paradise extract may be useful as a treatment for diabetes, however liver toxicity should be considered. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: H Hikino; Y Kiso; N Kato; Y Hamada; T Shioiri; R Aiyama; H Itokawa; F Kiuchi; U Sankawa Journal: J Ethnopharmacol Date: 1985-09 Impact factor: 4.360
Authors: Stephane L Ngahang Kamte; Farahnaz Ranjbarian; Gustavo Daniel Campagnaro; Prosper C Biapa Nya; Hélène Mbuntcha; Verlaine Woguem; Hilaire Macaire Womeni; Léon Azefack Ta; Cristiano Giordani; Luciano Barboni; Giovanni Benelli; Loredana Cappellacci; Anders Hofer; Riccardo Petrelli; Filippo Maggi Journal: Int J Environ Res Public Health Date: 2017-07-06 Impact factor: 3.390
Authors: Basiru O Ajiboye; Oluwafemi A Ojo; Oluwatosin Adeyonu; Oluwatosin D Imiere; Adewale O Fadaka; Adetutu O Osukoya Journal: J Evid Based Complementary Altern Med Date: 2016-12-30