| Literature DB >> 19878868 |
Abstract
Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.Entities:
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Year: 2009 PMID： 19878868 DOI： 10.1016/j.ccr.2009.10.007
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743