T Frodl1, J Stauber, N Schaaff, N Koutsouleris, J Scheuerecker, M Ewers, M Omerovic, M Opgen-Rhein, H Hampel, M Reiser, H-J Möller, E Meisenzahl. 1. Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience (TCIN), Trinity College, University of Dublin, Trinity Centre for Health Sciences, Trinity Academic Medical Centre [The Adelaide and Meath Hospital Incorporating the National Children's Hospital (AMNCH) and St. James's Hospital], Dublin 24, Ireland. thomas.frodl@tcd.ie
Abstract
OBJECTIVE: Results in adult attention deficit hyperactivity disorder (ADHD) on structural brain changes and the clinical relevance are contradictory. The aim of this study was to investigate whether in adult patients with ADHD hippocampal or amygdala volumes differs from that in healthy controls and patients with major depression (MD). METHOD: Twenty patients with ADHD, 20 matched patients with MD and 20 healthy controls were studied with high resolution magnetic resonance imaging. RESULTS: Amygdala volumes in patients with ADHD were bilaterally smaller than in patients with MD and healthy controls. In ADHD, more hyperactivity and less inattention were associated with smaller right amygdala volumes, and more symptoms of depression with larger amygdala volumes. CONCLUSION: This study supports findings that the amygdala plays an important role in the systemic brain pathophysiology of ADHD. Whether patients with ADHD and larger amygdala volumes are more vulnerable to affective disorders needs further investigation.
OBJECTIVE: Results in adult attention deficit hyperactivity disorder (ADHD) on structural brain changes and the clinical relevance are contradictory. The aim of this study was to investigate whether in adult patients with ADHD hippocampal or amygdala volumes differs from that in healthy controls and patients with major depression (MD). METHOD: Twenty patients with ADHD, 20 matched patients with MD and 20 healthy controls were studied with high resolution magnetic resonance imaging. RESULTS: Amygdala volumes in patients with ADHD were bilaterally smaller than in patients with MD and healthy controls. In ADHD, more hyperactivity and less inattention were associated with smaller right amygdala volumes, and more symptoms of depression with larger amygdala volumes. CONCLUSION: This study supports findings that the amygdala plays an important role in the systemic brain pathophysiology of ADHD. Whether patients with ADHD and larger amygdala volumes are more vulnerable to affective disorders needs further investigation.
Authors: Larry J Seidman; Joseph Biederman; Lichen Liang; Eve M Valera; Michael C Monuteaux; Ariel Brown; Jonathan Kaiser; Thomas Spencer; Stephen V Faraone; Nikos Makris Journal: Biol Psychiatry Date: 2010-12-23 Impact factor: 13.382
Authors: Chase C Dougherty; David W Evans; Scott M Myers; Gregory J Moore; Andrew M Michael Journal: Neuropsychol Rev Date: 2015-10-19 Impact factor: 7.444
Authors: Leslie A Hulvershorn; Maarten Mennes; F Xavier Castellanos; Adriana Di Martino; Michael P Milham; Tom A Hummer; Amy Krain Roy Journal: J Am Acad Child Adolesc Psychiatry Date: 2013-12-14 Impact factor: 8.829
Authors: Erik G Willcutt; Joel T Nigg; Bruce F Pennington; Mary V Solanto; Luis A Rohde; Rosemary Tannock; Sandra K Loo; Caryn L Carlson; Keith McBurnett; Benjamin B Lahey Journal: J Abnorm Psychol Date: 2012-05-21
Authors: Krista M Lisdahl; Leanne Tamm; Jeffery N Epstein; Terry Jernigan; Brooke S G Molina; Stephen P Hinshaw; James M Swanson; Erik Newman; Clare Kelly; James M Bjork Journal: Drug Alcohol Depend Date: 2016-02-06 Impact factor: 4.492