Literature DB >> 19875697

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation.

Nidhi Shrivastav1, Deyu Li, John M Essigmann.   

Abstract

The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA-damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.

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Year:  2009        PMID： 19875697      PMCID： PMC2802671          DOI： 10.1093/carcin/bgp262

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  162 in total

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Journal:  Nature       Date:  1982-04-22       Impact factor: 49.962

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Journal:  Nature       Date:  1982-04-22       Impact factor: 49.962

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Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

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Journal:  Chem Res Toxicol       Date:  1993 Sep-Oct       Impact factor: 3.739

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Journal:  J Biol Chem       Date:  1991-01-15       Impact factor: 5.157

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Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

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Journal:  EMBO J       Date:  1984-03       Impact factor: 11.598
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  112 in total

1.  Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells.

Authors:  Viviana de Rosa; Pinar Erkekoğlu; Anne Forestier; Alain Favier; Filiz Hincal; Alan M Diamond; Thierry Douki; Walid Rachidi
Journal:  Free Radic Res       Date:  2012-01-25

2.  Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.

Authors:  Dragony Fu; Leona D Samson
Journal:  DNA Repair (Amst)       Date:  2011-11-11

Review 3.  DNA damage by reactive species: Mechanisms, mutation and repair.

Authors:  N R Jena
Journal:  J Biosci       Date:  2012-07       Impact factor: 1.826

Review 4.  Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Authors:  Satya Narayan; Ritika Sharma
Journal:  Life Sci       Date:  2015-09-01       Impact factor: 5.037

5.  Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplex.

Authors:  Christopher Jacques Lech; Joefina Kim Cheow Lim; Jocelyn Mei Wen Lim; Samir Amrane; Brahim Heddi; Anh Tuân Phan
Journal:  Biophys J       Date:  2011-10-19       Impact factor: 4.033

Review 6.  Chemical Analysis of DNA Damage.

Authors:  Yang Yu; Pengcheng Wang; Yuxiang Cui; Yinsheng Wang
Journal:  Anal Chem       Date:  2017-11-07       Impact factor: 6.986

7.  Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA.

Authors:  Fangyi Chen; Qi Tang; Ke Bian; Zachary T Humulock; Xuedong Yang; Marco Jost; Catherine L Drennan; John M Essigmann; Deyu Li
Journal:  Chem Res Toxicol       Date:  2016-03-15       Impact factor: 3.739

Review 8.  Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.

Authors:  Ingrid Tessmer; Michael G Fried
Journal:  DNA Repair (Amst)       Date:  2014-02-16

9.  The roles of polymerases ν and θ in replicative bypass of O 6- and N 2-alkyl-2'-deoxyguanosine lesions in human cells.

Authors:  Hua Du; Pengcheng Wang; Jun Wu; Xiaomei He; Yinsheng Wang
Journal:  J Biol Chem       Date:  2020-02-25       Impact factor: 5.157

10.  Characterization of nitrogen mustard formamidopyrimidine adduct formation of bis(2-chloroethyl)ethylamine with calf thymus DNA and a human mammary cancer cell line.

Authors:  Francesca Gruppi; Leila Hejazi; Plamen P Christov; Sesha Krishnamachari; Robert J Turesky; Carmelo J Rizzo
Journal:  Chem Res Toxicol       Date:  2015-09-01       Impact factor: 3.739
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